Publication Name	World Journal of Gastroenterology
Manuscript ID	118185
Country	China

Category	Oncology
Manuscript Type	Observational Study
Article Title	Urinary N1, N12-diacetylspermine as a potential tumor biomarker for gastric and colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Hua-Zhen Zheng, Peng Wang, Hui-Jie Zheng, Zi-Qi Wang, Qi-Xin Li, Huan-Wei Chen, Huo-Qiang Chen and Qiu-Cheng Lei
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China (General Program) No. 82400651 Foshan Science and Technology Innovation Project No. 2320001006781
Corresponding Author	Qiu-Cheng Lei, Department of Hepatobiliary and Pancreatic Surgery, The First People’s Hospital of Foshan (Foshan Hospital Affiliated to Southern University of Science and Technology), School of Medicine, Southern University of Science and Technology, No. 81 Lingnan Avenue North, Foshan 528000, Guangdong Province, China. lqiuchenggd@163.com
Key Words	N1, N12-diacetylspermine; Tumor biomarker; Gastric cancer; Colorectal cancer; Urinary N1, N12-diacetylspermine; Liquid biopsy
Core Tip	Urinary N1, N12-diacetylspermine (DiAcSpm) was evaluated as a potential non-invasive biomarker for gastric and colorectal cancer. Levels were significantly elevated in cancer patients and showed moderate diagnostic value, which improved when combined with carcinoembryonic antigen. Urinary DiAcSpm levels decreased after chemotherapy in colorectal cancer patients, and high levels correlated with distant metastasis in gastric cancer patients. These findings support the potential of urinary DiAcSpm, though prospective studies in larger cohorts are warranted to confirm its clinical utility.
Citation	Zheng HZ, Wang P, Zheng HJ, Wang ZQ, Li QX, Chen HW, Chen HQ, Lei QC. Urinary N1, N12-diacetylspermine as a potential tumor biomarker for gastric and colorectal cancer. World J Gastroenterol 2026; In press

Received	2025-12-29 06:24
Peer-Review Started	2025-12-29 06:25
First Decision by Editorial Office Director	2026-01-23 09:28
Return for Revision	2026-01-23 09:28
Revised	2026-02-25 17:13
Publication Fee Transferred	2026-03-03 07:19
Second Decision by Editor	2026-04-10 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-10 08:12
Articles in Press	2026-04-10 08:12
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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