Publication Name	World Journal of Gastroenterology
Manuscript ID	118199
Country	Russia

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Gallbladder cancer: Is significant attention to this pathology justified?
Manuscript Source	Invited Manuscript
All Author List	Vladislav V Tsukanov, Alexander V Vasyutin, Edward V Kasparov and Julia L Tonkikh
Funding Agency and Grant Number
Corresponding Author	Vladislav V Tsukanov, Full Professor, MD, PhD, Clinical Department of the Digestive System Pathology of Adults and Children, Federal Research Center “Krasnoyarsk Science Center” of the Siberian Branch of the Russian Academy of Sciences, Scientific Research Institute of Medical Problems of the North, 3-G Partizan Zheleznyak Street, Krasnoyarsk 660022, Russia. gastro@impn.ru
Key Words	Gallbladder cancer; Bile acids; Gastrointestinal microbiota; Cholelithiasis; Epidemiology
Core Tip	Gallbladder cancer is characterized by high malignancy, a 5-year survival rate of less than 10%, and is extremely difficult to early diagnosis. Modern epidemiological studies highlight a strong association of gallbladder cancer with cholelithiasis, gastric cancer, hepatocellular carcinoma, pancreatic cancer and colorectal cancer. Investigation of the mechanisms of interaction between bile acids, gastrointestinal microbiota, the immune response, and metabolic pathways may be the primary pathogenetic paradigm for explaining this phenomenon and offers clear prospects for the development of new research directions to improve therapeutic and preventive technologies.
Citation	Tsukanov VV, Vasyutin AV, Kasparov EV, Tonkikh JL. Gallbladder cancer: Is significant attention to this pathology justified? World J Gastroenterol 2026; In press

Received	2025-12-28 08:37
Peer-Review Started	2025-12-28 08:38
First Decision by Editorial Office Director	2026-01-15 08:30
Return for Revision	2026-01-15 08:30
Revised	2026-01-28 10:22
Publication Fee Transferred
Second Decision by Editor	2026-03-10 02:47
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-10 08:15
Articles in Press	2026-03-10 08:15
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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