Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	118212
Country	China

Category	Surgery
Manuscript Type	Case Report
Article Title	Long-term survival after combined hepatectomy and colectomy for ruptured combined hepatocellular-cholangiocarcinoma with direct colonic invasion: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Chong-Wei Yang, Ri-Xin Zhang, Xiao-Lin Zheng, Ling Zhu, Zhi Zheng and Xin-Hua Wu
Funding Agency and Grant Number
Corresponding Author	Zhi Zheng, Department of Hepatobiliary Surgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, No. 26 Shengli Street, Jiang’an District, Wuhan 430014, Hubei Province, China. 13907164203@163.com
Key Words	Combined hepatocellular cholangiocarcinoma; Liver cancer rupture; Colonic invasion; Combined resection; Multimodal adjuvant therapy; Hepatocellular carcinoma; Case report
Core Tip	This study reports a successful case of staged multidisciplinary management for a life-threatening ruptured liver cancer with direct colonic invasion, pathologically confirmed as combined hepatocellular cholangiocarcinoma, a rare and aggressive histological subtype. The strategy involved initial embolization, followed by combined organ resection and modern adjuvant therapy, achieving over 42 months of long-term survival. The key finding is that tumor rupture should not be considered an absolute contraindication to curative treatment, and that aggressive surgical resection integrated with modern multimodal therapy can significantly improve outcomes even in such advanced cases.
Citation	Yang CW, Zhang RX, Zheng XL, Zhu L, Zheng Z, Wu XH. Long-term survival after combined hepatectomy and colectomy for ruptured combined hepatocellular-cholangiocarcinoma with direct colonic invasion: A case report. World J Gastrointest Oncol 2026; In press

Received	2025-12-29 06:18
Peer-Review Started	2025-12-29 06:18
First Decision by Editorial Office Director	2026-02-09 09:33
Return for Revision	2026-02-12 02:19
Revised	2026-02-25 17:00
Publication Fee Transferred	2026-03-04 12:06
Second Decision by Editor	2026-04-01 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-01 10:32
Articles in Press	2026-04-01 10:32
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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