Publication Name	World Journal of Hepatology
Manuscript ID	118215
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Discussion on the effect of Honghua Qinggan Shisanwei Wan on regulating macrophage polarization and alleviating liver injury
Manuscript Source	Unsolicited Manuscript
All Author List	Chun-Li Ma, Xin Zhang, Xu Bao, Lin-Yun Zhao, Li-Li Cao, Cheng-You Ma, Ting Zhang, Mei Hong, Yu-Long Bao and Rui-Ping Hu
Funding Agency and Grant Number	Funding Agency Grant Number Program for Innovative Research Team in Universities of lnner Mongolia Autonomous Region NMGIRT2418 Program for Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region NJYT23052 the Natural Science Foundation of Inner Mongolia 2024MS08054, 2024LHMS08024, 2023QN08059, 2025YQ037 the General Project of Inner Mongolia Medical University YKD2022MS006 the Key Project of Inner Mongolia Medical University YKD2022ZD008 Science and Technology Plan of the Inner Mongolia Automous Region 2021GG0098 Inner Mongolia Medical University 2025 Maker Cultivation Project 101322025138, 101322025102 the Duxue Talent Program of Inner Mongolia Medical University ZY20243102 the Shanxue Talent Program of Inner Mongolia Medical University ZY20242109 Research Fund for Post-doctoral Fellows to Stay in Mongolia after Completing Their Post-doctoral Programs
Corresponding Author	Yu-Long Bao, State Key Laboratory, Oncology Collaborative Innovation Center, School of Basic Medical Sciences, Inner Mongolia Medical University, No. 5 Xinhua Street, Hohhot 010100, Inner Mongolia Autonomous Region, China. yulongbao@immu.edu.cn
Key Words	Honghua Qinggan Shisanwei Wan; Macrophage polarization; Molecular docking; Liver injury; Inflammatory response
Core Tip	Honghua Qinggan Shisanwei Wan (HHQG), a traditional Mongolian medicinal formula, shows hepatoprotective potential. This study reveals HHQG inhibits M1 macrophage polarization and promotes M2 polarization, regulating the PPAR signaling pathway by upregulating nuclear receptors NR4A1 and NR4A2. Molecular docking confirms key compounds' stable binding with these receptors, highlighting HHQG's promise for treating liver-related disorders.
Citation	Ma CL, Zhang X, Bao X, Zhao LY, Cao LL, Ma CY, Zhang T, Hong M, Bao YL, Hu RP. Discussion on the effect of Honghua Qinggan Shisanwei Wan on regulating macrophage polarization and alleviating liver injury. World J Hepatol 2026; In press

Received	2025-12-29 06:49
Peer-Review Started	2025-12-29 06:50
First Decision by Editorial Office Director	2026-01-09 08:57
Return for Revision	2026-01-09 08:57
Revised	2026-01-23 06:51
Publication Fee Transferred	2026-01-28 02:52
Second Decision by Editor	2026-04-24 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-24 08:05
Articles in Press	2026-04-24 08:05
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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