Publication Name	World Journal of Experimental Medicine
Manuscript ID	118228
Country	Greece

Category	Endocrinology & Metabolism
Manuscript Type	Letter to the Editor
Article Title	Circadian and microbial misalignment in metabolic dysfunction-associated steatotic liver disease: Mechanistic insights and chronotherapeutic potential
Manuscript Source	Unsolicited Manuscript
All Author List	Christos Savvidis and Ioannis Ilias
Funding Agency and Grant Number
Corresponding Author	Ioannis Ilias, Director, MD, PhD, Department of Endocrinology, Hippocration General Hospital, No. 63 Evrou Street, Athens 11527, Greece. iiliasmd@yahoo.com
Key Words	Circadian disruption; Steatotic liver disease; Time-restricted eating; Melatonin; Chronotherapy
Core Tip	The gut-liver axis is a rhythmic system regulated by a bidirectional interaction between host clocks and the gut microbiota. Social jetlag disrupts the timing of metabolites and by compromising the intestinal barrier, which exacerbates metabolic injury in metabolic dysfunction-associated steatotic liver disease. Restoration of these rhythms through chronotherapeutic approaches provides an effective method to restore alignment and improve clinical outcomes.
Citation	Savvidis C, Ilias I. Circadian and microbial misalignment in metabolic dysfunction-associated steatotic liver disease: Mechanistic insights and chronotherapeutic potential. World J Exp Med 2026; In press

Received	2025-12-31 02:34
Peer-Review Started	2025-12-31 02:34
First Decision by Editorial Office Director	2026-01-20 09:17
Return for Revision	2026-01-20 09:17
Revised	2026-01-22 12:08
Publication Fee Transferred
Second Decision by Editor	2026-02-04 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-04 09:18
Articles in Press	2026-02-04 09:18
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-315x (online)
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