Publication Name	World Journal of Gastroenterology
Manuscript ID	118233
Country	Egypt

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Decoding intrahepatic cholangiocarcinoma through lactate metabolism: From cellular states to therapeutic targets
Manuscript Source	Invited Manuscript
All Author List	Yasser Fouad, Ahmed Gomaa and Gamal Esmat
Funding Agency and Grant Number
Corresponding Author	Yasser Fouad, MD, Professor, Department of Gastroenterology, Hepatology and Endemic Medicine, Faculty of Medicine, Minia University, El-Horria Stree, Minia 19111, Egypt. yasser.abdallah@mu.edu.eg
Key Words	Intrahepatic cholangiocarcinoma; Lactate metabolism; Tumor heterogeneity; Single-cell transcriptomics; Tumor microenvironment; Metabolic reprogramming
Core Tip	Lactate metabolism organises intrahepatic cholangiocarcinoma heterogeneity, linking metabolic activity to cellular hierarchy, mitochondrial function, and immune evasion, offering new avenues for stratification and therapy.
Citation	Fouad Y, Gomaa A, Esmat G. Decoding intrahepatic cholangiocarcinoma through lactate metabolism: From cellular states to therapeutic targets. World J Gastroenterol 2026; In press

Received	2025-12-30 06:15
Peer-Review Started	2025-12-30 06:16
First Decision by Editorial Office Director	2026-02-03 10:21
Return for Revision	2026-02-03 10:21
Revised	2026-02-05 05:01
Publication Fee Transferred
Second Decision by Editor	2026-02-12 02:50
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-12 08:18
Articles in Press	2026-02-12 08:18
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
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