Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	118256
Country	China

Category	Oncology
Manuscript Type	Opinion Review
Article Title	Novel regulatory network of PS-1/β-catenin/p-PTEN axis in gastric cancer invasion
Manuscript Source	Invited Manuscript
All Author List	Shuai Xiao, Dan-Dan Song, Ye-Ping Yu, Xiao-Zhen Xu, Jing-Feng Tang and Ce-Fan Zhou
Funding Agency and Grant Number	Funding Agency Grant Number the National Natural Science Foundation of China 32571378, 32270768, 82273970, U25A20650, 82370715 the Key Cultivation Project of Hubei Province for Science and Technology 2024DJA037 National Natural Science Foundation of Hubei 2025AFA085
Corresponding Author	Ce-Fan Zhou, Professor, School of Life and Health Sciences, Institute of Biomedical Research, National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, No. 28 Nanli Road, Wuhan 430068, Hubei Province, China. cefan@hbut.edu.cn
Key Words	Gastric cancer; Presenilin-1; Phosphatase and tensin homolog; β-Catenin; Tumor metastasis; γ-secretase inhibitor
Core Tip	Gastric cancer (GC) is a type of malignant tumor with high mortality and morbidity rates. Tumor metastasis and recurrence are among the main causes of death for GC patients, yet the specific mechanisms behind them remain unclear. The study reveals the regulatory correlation among presenilin-1, β-catenin, and phosphorylated phosphatase and tensin homolog in GC and their combined role in GC cell invasion.
Citation	Xiao S, Song DD, Yu YP, Xu XZ, Tang JF, Zhou CF. Novel regulatory network of PS-1/β-catenin/p-PTEN axis in gastric cancer invasion. World J Gastrointest Oncol 2026; In press

Received	2025-12-28 14:19
Peer-Review Started	2025-12-28 14:19
First Decision by Editorial Office Director	2026-01-09 07:52
Return for Revision	2026-01-09 07:52
Revised	2026-01-22 03:41
Publication Fee Transferred
Second Decision by Editor	2026-04-09 02:32
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-09 06:21
Articles in Press	2026-04-09 06:21
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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