Publication Name	World Journal of Clinical Cases
Manuscript ID	118263
Country	India

Category	Ophthalmology
Manuscript Type	Review
Article Title	Areas of uncertainty in endophthalmitis care
Manuscript Source	Invited Manuscript
All Author List	Ramesh Venkatesh, Prathibha Hande, Edwin James, Nagesha Krishnappa Chokkahalli, Prashanth Ranganath, Rupal Kathare, Vishma Prabhu, Chaitra Jayadev, Karishma Tendulkar, Pragati Raj, Gaurav Malwe, Shubhangi Tripathi, Preksha Biradar, Alisha Sirsikar and Naresh Kumar Yadav
Funding Agency and Grant Number
Corresponding Author	Ramesh Venkatesh, Consultant, Department of Ophthalmology, Narayana Nethralaya, 121/C. 1st R block, West of Chord Road, Rajaji Nagar, Bangalore 560010, India. vramesh80@yahoo.com
Key Words	Endophthalmitis; Diagnostic uncertainty; Intravitreal therapy; Vitrectomy timing; Antimicrobial resistance
Core Tip	Endophthalmitis remains a vision-threatening ophthalmic emergency in which clinicians must make urgent decisions despite substantial diagnostic and therapeutic uncertainty. Overlapping clinical presentations, frequent culture negativity, evolving antimicrobial resistance, and variable response to treatment complicate early management. Key controversies persist regarding the timing and extent of vitrectomy, selection and dosing of intravitreal antimicrobials, and the role of adjunctive corticosteroids. This review highlights these real-world gray zones and emphasizes the need for individualized, adaptive decision-making rather than rigid, algorithm-based approaches.
Citation	Venkatesh R, Hande P, James E, Chokkahalli NK, Ranganath P, Kathare R, Prabhu V, Jayadev C, Tendulkar K, Raj P, Malwe G, Tripathi S, Biradar P, Sirsikar A, Yadav NK. Areas of uncertainty in endophthalmitis care. World J Clin Cases 2026; In press

Received	2025-12-28 14:29
Peer-Review Started	2025-12-28 14:30
First Decision by Editorial Office Director	2026-01-09 07:48
Return for Revision	2026-01-09 07:48
Revised	2026-01-12 15:01
Publication Fee Transferred
Second Decision by Editor	2026-02-06 02:48
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-06 07:14
Articles in Press	2026-02-06 07:14
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com