Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	118300
Country	Egypt

Category	Medicine, General & Internal
Manuscript Type	Randomized Controlled Trial
Article Title	Bovine colostrum for prevention of recurrent urinary tract infections in susceptible children: A randomized controlled trial
Manuscript Source	Invited Manuscript
All Author List	Ragia M Said, Abanoub A Wissa, Sara T Wahib and Noha U Hashem
Funding Agency and Grant Number
Corresponding Author	Ragia M Said, Professor, Divsion of Pediatric Nephrology, Department of Pediatrics, Faculty of Medicine, Ain Shams University., Abbaseyah, Cairo 1181, Egypt. ragia_marei@med.asu.edu.eg
Key Words	Recurrent urinary tract infections; respiratory tract infections; gastrointestinal infections; Children; Bovine colostrum
Core Tip	Recurrent urinary tract infections (UTIs) promote the progression of kidney damage in children with congenital anomalies of the kidney and urinary tract, potentially leading to chronic kidney disease. The rising burden of antimicrobial resistance highlights the need for effective nonantibiotic preventive strategies. This randomized, double-blinded, placebo-controlled trial explores oral bovine colostrum (BC), a bioactive prebiotic with immunomodulatory properties, as an adjuvant therapy in these children. Although overall UTIs reduction was not statistically significant, BC significantly reduced cystitis, and showed delayed, month-specific reductions in UTIs, alongside fewer respiratory and gastrointestinal infections. These findings suggest a potential cumulative immunomodulatory benefit of BC in vulnerable pediatric populations.
Citation	Said RM, Wissa AA, Wahib ST, Hashem NU. Bovine colostrum for prevention of recurrent urinary tract infections in susceptible children: A randomized controlled trial. World J Clin Pediatr 2026; In press

Received	2025-12-29 03:16
Peer-Review Started	2025-12-29 03:21
First Decision by Editorial Office Director	2026-01-14 08:15
Return for Revision	2026-01-14 08:15
Revised	2026-01-27 16:23
Publication Fee Transferred
Second Decision by Editor	2026-03-17 03:05
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-17 06:28
Articles in Press	2026-03-17 06:28
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2219-2808 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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