Publication Name	World Journal of Gastroenterology
Manuscript ID	118301
Country	China

Category	Medicine, General & Internal
Manuscript Type	Retrospective Cohort Study
Article Title	Risk-stratified assessment of 180-day mortality in severe alcoholic hepatitis
Manuscript Source	Unsolicited Manuscript
All Author List	Yi-Wen Xv, Jun Ling, Xiao-Gang Hao, Tian-Jiao Xu, Hua Tian, Sa Lv, Shao-Li You and Bing Zhu
Funding Agency and Grant Number	Funding Agency Grant Number Capital’s Funds for Health Improvement and Research, China 2024-1-2181 National Science and Technology Major Projects of China 2025ZD01906302
Corresponding Author	Bing Zhu, Senior Department of Hepatology, The Fifth Medical Center of Chinese PLA General Hospital, 100 West Fourth Ring Middle Road, Fengtai District, Beijing, Beijing 100039, China. zhubing302@163.com
Key Words	Maddrey discriminant function; Model for end-stage liver disease; Machine learning; Prognosis; Predictive model
Core Tip	This study identified distinct clinical phenotypes of severe alcoholic hepatitis (SAH) using interpretable machine learning, enhancing prognosis precision. By analyzing 1536 patients, we found that creatinine and total bilirubin levels are key predictors of 180-day mortality. A novel two-step risk stratification model revealed significant mortality variations, classifying patients into four tiers with survival rates ranging from 5% to over 50%. This tool facilitates rapid risk assessment and informed treatment decisions, marking a significant advancement in managing SAH.
Citation	Xv YW, Ling J, Hao XG, Xu TJ, Tian H, Lv S, You SL, Zhu B. Risk-stratified assessment of 180-day mortality in severe alcoholic hepatitis. World J Gastroenterol 2026; In press

Received	2026-01-06 07:18
Peer-Review Started	2026-01-06 07:20
First Decision by Editorial Office Director	2026-01-30 09:09
Return for Revision	2026-01-30 09:09
Revised	2026-02-12 16:34
Publication Fee Transferred
Second Decision by Editor	2026-04-13 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-13 07:52
Articles in Press	2026-04-13 07:52
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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