Publication Name	World Journal of Nephrology
Manuscript ID	118309
Country	Singapore

Category	Urology & Nephrology
Manuscript Type	Review
Article Title	Critical care considerations in rhabdomyolysis-associated acute kidney injury and kidney replacement therapy
Manuscript Source	Invited Manuscript
All Author List	Faith Hui Ai Wong and Kay Choong See
Funding Agency and Grant Number
Corresponding Author	Faith Hui Ai Wong, Department of Medicine, National University Hospital, Level 10 NUHS Tower Block, / 119228, Singapore. faithwonghuiai@u.nus.edu
Key Words	Rhabdomyolysis; Rhabdomyolysis-associated acute kidney injury; Acute kidney injury; Kidney replacement therapy; Critical care; Myoglobinuria; Acute kidney injury biomarkers; Management of rhabdomyolysis
Core Tip	Rhabdomyolysis-associated acute kidney injury (AKI) remains a serious concern in critical care, with management strategies often limited by a lack of clinical evidence. This review synthesises underlying pathophysiological mechanisms, current established and novel biomarkers, early AKI risk prediction scores and key management strategies, including fluid resuscitation and addressing debates regarding urine alkalisation and the role of kidney replacement therapy. By integrating a holistic understanding of pathophysiology with evidence-guided clinical practice, this article supports more informed and individualised care for critically ill patients with rhabdomyolysis-associated AKI, while highlighting possible future therapeutic directions.
Citation	Wong FHA, See KC. Critical care considerations in rhabdomyolysis-associated acute kidney injury and kidney replacement therapy. World J Nephrol 2026; In press

Received	2025-12-29 03:23
Peer-Review Started	2025-12-29 03:23
First Decision by Editorial Office Director	2026-01-19 08:51
Return for Revision	2026-01-19 08:51
Revised	2026-02-28 09:26
Publication Fee Transferred
Second Decision by Editor	2026-03-23 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-23 06:58
Articles in Press	2026-03-23 06:58
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-6124 (online)
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