Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	118336
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Correlation and clinical significance of hepcidin and STAT3 in colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Kang-Bao Li, Qiao-Zhen Hu, Jie Li, Zhong-Yan Li, Kai-Yu Feng, Min Ye, Duo Luo, Xin-Yue Zhang, Shi Zhang and Peng Chen
Funding Agency and Grant Number	Funding Agency Grant Number Guangzhou Science and Technology Program 2024A03J1024 Guangzhou Science and Technology Program 2024A04J3997
Corresponding Author	Peng Chen, PhD, Department of Geriatrics, Gastroenterology Ward, Guangzhou First People’s Hospital, the Second Affiliated Hospital, School of Medicine, South China University of Technology, NO. 1, Panfu Road, Guangzhou 510180, Guangdong Province, China. p2830chenp@sina.com
Key Words	Hepcidin; STAT3; Colorectal cancer; Clinical significance; Lymph node metastasis
Core Tip	Iron metabolism disorders play a pivotal role in colorectal cancer (CRC) development and progression, with this disordered state closely associated with hepcidin and signal transducer and activator of transcription 3 (STAT3) dysregulation. As a vital transcription factor, STAT3, upon activation, translocates to the cell nucleus and directly binds to the hepcidin gene promoter region, thereby upregulating hepcidin expression. Concurrently, CRC cells adapt to iron overload environments by modulating the expression of iron metabolism-related proteins. This study aims to investigate the expression profiling and characteristics of hepcidin and STAT3, iron metabolism indicators, in patients with CRC.
Citation	Li KB, Hu QZ, Li J, Li ZY, Feng KY, Ye M, Luo D, Zhang XY, Zhang S, Chen P. Correlation and clinical significance of hepcidin and STAT3 in colorectal cancer. World J Gastrointest Surg 2026; In press

Received	2026-02-10 10:00
Peer-Review Started	2026-02-10 10:00
First Decision by Editorial Office Director	2026-02-28 06:16
Return for Revision	2026-02-28 06:16
Revised	2026-03-05 12:39
Publication Fee Transferred	2026-03-09 12:12
Second Decision by Editor	2026-03-25 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-25 05:39
Articles in Press	2026-03-25 05:39
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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