Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	118341
Country	China

Category	Surgery
Manuscript Type	Editorial
Article Title	Endoscopic submucosal dissection for early gastric cancer: A comparative review of efficacy outcomes with gastrectomy
Manuscript Source	Invited Manuscript
All Author List	Yu-Lian Zhang, Liang Zong and Hai-Bo Hu
Funding Agency and Grant Number
Corresponding Author	Liang Zong, MD, PhD, Department of Gastrointestinal Surgery, The Affiliated Hospital of Changzhi Medical College, Changzhi People’s Hospital, No. 502 Changxing Middle Road, Changzhi 046000, Shanxi Province, China. 250537471@qq.com
Key Words	Efficacy; Endoscopic submucosal dissection; Early gastric lesion; Gastrectomy; Safety
Core Tip	This editorial concerns a retrospective cohort study of 206 patients (citing research from Sichuan North Medical University Affiliated Hospital) and incorporates an authoritative guideline: The Japanese Gastric Cancer Treatment Guidelines 2021 (6th edition). Absolute indications for endoscopic mucosal resection or endoscopic submucosal dissection (ESD) include: (1) Differentiated-type adenocarcinoma without ulcer; (2) Depth of invasion clinically T1a; and (3) Lesion diameter ≤ 2 cm. Additional ESD indications: (1) Differentiated-type adenocarcinoma with ulcer (diameter ≤ 3 cm); and (2) Undifferentiated-type adenocarcinoma (diameter ≤ 2 cm). Selection criteria include: (1) Subjects with stage T1 gastric cancer or high-grade intraepithelial neoplasia (precancerous lesion); (2) Direct comparison between ESD and surgical gastrectomy (including open/laparoscopic approaches): Reporting at least one core outcome (complete resection rate, complications, recurrence rate, survival rate); and (3) Sample size ≥ 50 cases with follow-up duration ≥ 12 months.
Citation	Zhang YL, Zong L, Hu HB. Endoscopic submucosal dissection for early gastric cancer: A comparative review of efficacy outcomes with gastrectomy. World J Gastrointest Surg 2026; In press

Received	2025-12-30 06:03
Peer-Review Started	2025-12-30 06:03
First Decision by Editorial Office Director	2026-01-06 06:11
Return for Revision	2026-01-06 06:11
Revised	2026-01-15 07:26
Publication Fee Transferred
Second Decision by Editor	2026-02-06 02:54
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-06 06:09
Articles in Press	2026-02-06 06:09
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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