Publication Name	World Journal of Gastroenterology
Manuscript ID	118346
Country	China

Category	Oncology
Manuscript Type	Editorial
Article Title	From local eradication to immune priming: Paradigm shift of hyperthermic intraperitoneal chemotherapy in gastric cancer therapy
Manuscript Source	Invited Manuscript
All Author List	Chun-Xiao Ni and Jia-Ju Xu
Funding Agency and Grant Number	Funding Agency Grant Number Scientific Research Fund of Tai’an Science and Technology Agency No. 2019NS180
Corresponding Author	Jia-Ju Xu, MD, Department of Medical Oncology, Tai’an City Central Hospital, No. 29 Longtan Road, Tai’an 271000, Shandong Province, China. jiajuxu1101@163.com
Key Words	Gastric cancer; Hyperthermic intraperitoneal chemotherapy; Tumor immune microenvironment; Immunogenic cell death; Immune checkpoint inhibitors
Core Tip	Postoperative hyperthermic intraperitoneal chemotherapy should be reconceptualized as an immunogenic primer that activates systemic anti-tumor immunity, rather than be viewed merely as a local cytoreductive treatment. This repositions hyperthermic intraperitoneal chemotherapy as a strategic foundation for synergistic combination with immune-checkpoint inhibitors. Consequently, future research should prioritize the definition of optimal synergistic sequences and the identification of predictive biomarkers to pave the way for this precision immunotherapy strategy.
Citation	Ni CX, Xu JJ. From local eradication to immune priming: Paradigm shift of hyperthermic intraperitoneal chemotherapy in gastric cancer therapy. World J Gastroenterol 2026; In press

Received	2025-12-30 06:09
Peer-Review Started	2025-12-30 06:10
First Decision by Editorial Office Director	2026-01-07 10:28
Return for Revision	2026-01-07 10:28
Revised	2026-01-13 12:22
Publication Fee Transferred
Second Decision by Editor	2026-02-05 02:47
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-05 08:51
Articles in Press	2026-02-05 08:51
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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