Publication Name	World Journal of Methodology
Manuscript ID	118399
Country	India

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Management of constipation: A narrative review of evolving strategies and methodological challenges
Manuscript Source	Invited Manuscript
All Author List	Manjeet Kumar Goyal, Gayatri Brahmandam, Rishi Chowdhary, Sowmya Durga Subhasri Guna, Dhruvi Shah, Prerna Goyal, Ashita Rukmini Vuthaluru and Omesh Goyal
Funding Agency and Grant Number
Corresponding Author	Omesh Goyal, Department of Gastroenterology, Dayanand Medical College and Hospital, Tagore Nagar, Ludhiana 141001, Punjab, India. dromeshgoyal@gmail.com
Key Words	Constipation; Gastrointestinal motility disorders; Irritable bowel syndrome; Defecation disorders; Colonic transit; Pelvic floor disorders; Prokinetic agents; Disorders of gut-brain interactions
Core Tip	Chronic constipation is a heterogeneous disorder encompassing distinct pathophysiologic phenotypes, including normal-transit constipation, slow-transit constipation, and defecatory disorders, as well as a broad range of secondary organic causes. Failure to recognize these subtypes contributes to suboptimal treatment responses and inconsistent outcomes in both clinical practice and trials. Accurate diagnosis requires a structured, stepwise approach integrating careful history, targeted physical examination, and selective use of physiologic and imaging investigations. Management should be phenotype-driven, combining lifestyle measures, pharmacologic therapy, and pelvic floor–directed interventions when appropriate. Emphasizing mechanism-based evaluation and individualized treatment strategies is essential to improve long-term outcomes and reduce unnecessary therapeutic escalatio
Citation	Goyal MK, Brahmandam G, Chowdhary R, Guna SDS, Shah D, Goyal P, Vuthaluru AR, Goyal O. Management of constipation: A narrative review of evolving strategies and methodological challenges. World J Methodol 2026; In press

Received	2025-12-31 01:22
Peer-Review Started	2025-12-31 01:22
First Decision by Editorial Office Director	2026-01-23 09:17
Return for Revision	2026-01-23 09:17
Revised	2026-01-26 12:55
Publication Fee Transferred
Second Decision by Editor	2026-02-25 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-25 07:16
Articles in Press	2026-02-25 07:16
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2222-0682 (online)
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