Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	118400
Country	Sweden

Category	Surgery
Manuscript Type	Retrospective Cohort Study
Article Title	Prophylactic sodium thiosulfate reduces the risk and severity of acute kidney injury in oxaliplatin-based hyperthermic intraperitoneal chemotherapy
Manuscript Source	Unsolicited Manuscript
All Author List	Nader Algethami, Valentinus Valdimarsson, Victor Verwaal and Ingvar Syk
Funding Agency and Grant Number
Corresponding Author	Nader Algethami, MD, Department of Surgery, Skane University Hospital, Inga Marie Nilssons gata 38, Malmo 21428, Skane, Sweden. nader.algethami@med.lu.se
Key Words	Hyperthermic intraperitoneal chemotherapy; Peritoneal carcinomatosis; Peritoneal surface malignancy; Oxaliplatin; Acute kidney injury; Sodium thiosulfate
Core Tip	This retrospective single-center study demonstrates that prophylactic sodium thiosulfate (ST) markedly reduces both the incidence and severity of acute kidney injury in patients undergoing cytoreductive surgery with oxaliplatin-based hyperthermic intraperitoneal chemotherapy for colorectal peritoneal carcinomatosis. Patients receiving ST showed significantly lower postoperative creatinine levels and fewer kidney injuries without an increased risk of other postoperative complications. These findings indicate a clear nephroprotective benefit in this setting and support consideration of ST in oxaliplatin-based hyperthermic intraperitoneal chemotherapy protocols, although future prospective studies are warranted to confirm these results.
Citation	Algethami N, Valdimarsson V, Verwaal V, Syk I. Prophylactic sodium thiosulfate reduces the risk and severity of acute kidney injury in oxaliplatin-based hyperthermic intraperitoneal chemotherapy. World J Gastrointest Oncol 2026; In press

Received	2025-12-31 02:42
Peer-Review Started	2025-12-31 02:44
First Decision by Editorial Office Director	2026-01-14 02:55
Return for Revision	2026-01-14 02:55
Revised	2026-01-28 00:50
Publication Fee Transferred	2026-02-09 11:45
Second Decision by Editor	2026-04-08 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-08 08:05
Articles in Press	2026-04-08 08:05
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com