Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	118413
Country	India

Category	Pediatrics
Manuscript Type	Prospective Study
Article Title	Transforming central line associated blood stream infection prevention in neonates: Results from a multimodal quality improvement initiative
Manuscript Source	Invited Manuscript
All Author List	Anish Pillai, Nandkishor Kabra, Anuja Nayak, Mayuri Bhanushali, Haribalakrishna Balasubramanian and Sandesh Shivananda
Funding Agency and Grant Number
Corresponding Author	Nandkishor Kabra, Head, Professor, Department of Neonatology, Surya Hospitals, Mangal Ashirvad, S.V Road, Santacruz West, Mumbai 400054, Mahārāshtra, India. drkabra@suryahospitals.com
Key Words	Quality improvement; Plan-Do-Study-Act cycle; Neonatal sepsis; Prevention bundle; Infection control; Central line-associated bloodstream infections
Core Tip	A structured, multimodal quality improvement initiative led to a substantial and sustained reduction in neonatal central line associated blood stream infection rates in a level-3 neonatal intensive care unit. By strengthening hand hygiene, customizing central line care bundles, reinforcing environmental cleaning, conducting regular audits, and providing ongoing nursing education through iterative Plan-Do-Study-Act cycles, central line associated blood stream infection rates fell by over 80% and remained low for 18 months. This low-cost, pragmatic approach is feasible and reproducible in resource-constrained neonatal intensive care unit settings, including low- and middle-income countries.
Citation	Pillai A, Kabra N, Nayak A, Bhanushali M, Balasubramanian H, Shivananda S. Transforming central line associated blood stream infection prevention in neonates: Results from a multimodal quality improvement initiative. World J Clin Pediatr 2026; In press

Received	2026-01-15 03:41
Peer-Review Started	2026-01-15 03:45
First Decision by Editorial Office Director	2026-02-03 09:44
Return for Revision	2026-02-03 09:44
Revised	2026-02-21 18:12
Publication Fee Transferred
Second Decision by Editor	2026-04-08 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-08 07:33
Articles in Press	2026-04-08 07:33
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2219-2808 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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