Publication Name	World Journal of Gastroenterology
Manuscript ID	118416
Country	China

Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Predictive value of neutrophil-lymphocyte ratio for prognosis in patients with advanced hepatocellular carcinoma treated with programmed cell death 1 inhibitors
Manuscript Source	Unsolicited Manuscript
All Author List	Rui Guo and Meng Gao
Funding Agency and Grant Number
Corresponding Author	Rui Guo, Department of Laboratory Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, No. 7 Weiwu Road, Jinshui District, Zhengzhou 462000, Henan Province, China. guorui2460@163.com
Key Words	Neutrophil-lymphocyte ratio; Hepatocellular carcinoma; Programmed cell death 1 inhibitor; Prognosis; Biomarker; Immunotherapy
Core Tip	This study demonstrates that a high pretreatment neutrophil-lymphocyte ratio (NLR) is an independent predictor of poor response and survival in advanced hepatocellular carcinoma patients treated with programmed cell death 1 inhibitors. NLR reflects a systemic inflammatory state that may undermine immunotherapy efficacy. Our findings support the use of this simple, cost-effective biomarker for risk stratification and treatment personalization in the immunotherapy era.
Citation	Guo R, Gao M. Predictive value of neutrophil-lymphocyte ratio for prognosis in patients with advanced hepatocellular carcinoma treated with programmed cell death 1 inhibitors. World J Gastroenterol 2026; In press

Received	2026-01-09 09:59
Peer-Review Started	2026-01-09 09:59
First Decision by Editorial Office Director	2026-01-20 09:21
Return for Revision	2026-01-20 09:21
Revised	2026-01-30 02:08
Publication Fee Transferred	2026-02-03 07:57
Second Decision by Editor	2026-03-17 03:07
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-17 10:17
Articles in Press	2026-03-17 10:17
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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