Publication Name	World Journal of Clinical Cases
Manuscript ID	118420
Country	India

Category	Clinical Neurology
Manuscript Type	Minireviews
Article Title	Temporal lobe epilepsy as a model of accelerated brain aging: Roles of biological aging markers and microRNA dysregulation
Manuscript Source	Invited Manuscript
All Author List	Rekha Dwivedi, Rashmi Gupta, Monika Pahuja, Jasmine Parihar, Manjari Tripathi, Rima Dada and Prabhakar Tiwari
Funding Agency and Grant Number
Corresponding Author	Prabhakar Tiwari, PhD, Senior Researcher, Department of Anatomy, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, Delhi, India. prabhakt@gmail.com
Key Words	Temporal lobe epilepsy, Biological aging markers; Epigenetics; MicroRNAs; Epileptogenesis
Core Tip	Temporal lobe epilepsy (TLE) is traditionally viewed as a seizure disorder, but evidence indicates it is a progressive condition resembling accelerated brain aging. Patients with chronic TLE show early cognitive decline, hippocampal atrophy, neuroinflammation, and neurodegenerative changes beyond age expectations. This mini-review highlights key aging hallmarks in TLE, including oxidative stress, mitochondrial dysfunction, chronic inflammation (“inflammaging”), impaired proteostasis, and autophagy dysregulation, and emphasizes microRNAs as epigenetic regulators linking epileptogenesis to neuronal aging. Understanding these mechanisms may aid biomarker development and inspire disease-modifying therapeutic strategies beyond seizure control.
Citation	Dwivedi R, Gupta R, Pahuja M, Parihar J, Tripathi M, Dada R, Tiwari P. Temporal lobe epilepsy as a model of accelerated brain aging: Roles of biological aging markers and microRNA dysregulation. World J Clin Cases 2026; In press

Received	2026-01-02 13:40
Peer-Review Started	2026-01-02 13:45
First Decision by Editorial Office Director	2026-01-16 06:42
Return for Revision	2026-01-16 06:42
Revised	2026-01-20 04:54
Publication Fee Transferred
Second Decision by Editor	2026-02-10 02:45
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-10 07:22
Articles in Press	2026-02-10 07:22
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com