Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	118421
Country	India

Category	Pediatrics
Manuscript Type	Observational Study
Article Title	Study on intravenous immunoglobulin use in a pediatric intensive care unit of a tertiary care center
Manuscript Source	Invited Manuscript
All Author List	Poovazhagi Varadarajan, Seenivasan Subramani, Vasanth Jeyaram, Lakshmi S Velmurugan, Raghul Jayaseelan and Gomathy Srividya Venugopal
Funding Agency and Grant Number
Corresponding Author	Seenivasan Subramani, Assistant Professor, Consultant, DM, Department of Pediatric Intensive Care, Institute of Child Health and Hospital for Children, Madras Medical College, Tamil Salai, Egmore Chennai, Chennai 600008, Tamil Nādu, India. seeni.sholing@gmail.com
Key Words	Intravenous immunoglobulin; Pediatric intensive care unit; Off label use; Strength of recommendation; Level of evidence
Core Tip	This study evaluates intravenous immunoglobulin (IVIG) use in a pediatric intensive care unit, highlighting indications, dosing, evidence support, and outcomes. The commonest indication was immunological diseases followed by neurological illness, infections, hematological diseases and cardiac diseases. Strength of recommendation varies in different diseases. Off label use was seen in about one -fifth of patients. Adverse effects were minimal. Evidence is lacking regarding the use of IVIG in many diseases. The study suggests multicentric trials to define proper indications of IVIG.
Citation	Varadarajan P, Subramani S, Jeyaram V, Velmurugan LS, Jayaseelan R, Venugopal GS. Study on intravenous immunoglobulin use in a pediatric intensive care unit of a tertiary care center. World J Clin Pediatr 2026; In press

Received	2026-01-07 03:33
Peer-Review Started	2026-01-07 03:33
First Decision by Editorial Office Director	2026-01-16 06:53
Return for Revision	2026-01-16 06:53
Revised	2026-01-29 11:43
Publication Fee Transferred
Second Decision by Editor	2026-02-13 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-13 05:48
Articles in Press	2026-02-13 05:48
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2219-2808 (online)
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