Publication Name	World Journal of Transplantation
Manuscript ID	118450
Country	Saudi Arabia

Category	Transplantation
Manuscript Type	Retrospective Study
Article Title	Immunologic clustering of donor-specific antibodies and clinical outcomes in kidney transplant recipients
Manuscript Source	Invited Manuscript
All Author List	Salem H Al-Qurashi, Muhammad Abdul Mabood Khalil, Hinda Hassan Khideer Mahmood, Maram Majid Alsharif, Yara Faisal Alqurashi, Lama Alghamdi, Rawan A Al-Ghamdi, Zeyad Adel Alsaedi, Aileen Jean Dela Cruz, Ghaleb A Aboasamh and Nihal Mohammed Sadagah
Funding Agency and Grant Number
Corresponding Author	Muhammad Abdul Mabood Khalil, FRCP, Center of Renal Diseases and Transplantation, King Fahad Armed Forces Hospital, Al Kurnaysh Br Road, Al Andalus, Jeddah 23311, Makkah al Mukarramah, Saudi Arabia. doctorkhalil1975@hotmail.com
Key Words	Immunological clustering; Donor-specific antibodies; Renal allograft outcomes; Machine learning; Human leukocytes antigen
Core Tip	Donor-specific antibodies (DSA) in kidney transplant recipients (KTR) are associated with variable immunologic risk, which is not always well defined by DSA class or mean fluorescence intensity alone. In this study, an unsupervised machine learning approach was used to group DSA-positive recipients based on antibody characteristics and transplant-related factors. These groups showed apparent differences in early post-transplant risk profiles. Patients with broader and stronger antibody responses were more likely to experience adverse early outcomes, whereas those with a limited antibody burden had favorable graft function. This approach may help refine risk assessment and support more individualized management of DSA-positive KTR.
Citation	Al-Qurashi SH, Khalil MAM, Mahmood HHK, Alsharif MM, Alqurashi YF, Alghamdi L, Al-Ghamdi RA, Alsaedi ZA, Cruz AJD, Aboasamh G, Sadagah NM. Immunologic clustering of donor-specific antibodies and clinical outcomes in kidney transplant recipients. World J Transplant 2026; In press

Received	2026-01-06 06:32
Peer-Review Started	2026-01-06 06:42
First Decision by Editorial Office Director	2026-02-09 09:32
Return for Revision	2026-02-09 09:32
Revised	2026-02-28 20:47
Publication Fee Transferred
Second Decision by Editor	2026-04-01 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-01 08:41
Articles in Press	2026-04-01 08:41
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3230 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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