Publication Name	World Journal of Gastroenterology
Manuscript ID	118486
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Case Control Study
Article Title	Chicken skin mucosa is independently associated with advanced colorectal adenoma with transmembrane member 16A potentially involved in this association
Manuscript Source	Unsolicited Manuscript
All Author List	Rui-Jie Wang, Yang Hu and Shi-Bin Guo
Funding Agency and Grant Number
Corresponding Author	Shi-Bin Guo, Department of Gastroenterology, The First Affiliated Hospital of Dalian Medical University, No. 222 Zhongshan Road, Xigang District, Dalian 116001, Liaoning Province, China. guoshibin@firsthosp-dmu.com
Key Words	Chicken skin mucosa; Adenoma; Advanced adenoma; Transmembrane member 16A
Core Tip	Chicken skin mucosa (CSM) is an endoscopic, pale-yellow, speckled pattern appearing on colorectal mucosa, typically adjacent to colorectal neoplasm. Our study demonstrated that CSM is independently associated with advanced colorectal adenomas, featuring characteristics such as large size, multiple occurrences, distal location, protruding morphology, and dysplastic histology. Transmembrane member 16A (a calcium-activated chloride channel) expression was significantly higher in advanced than non-advanced adenomas based on immunohistochemistry. The independent link between CSM and advanced colorectal adenoma offers valuable insights for improved clinical decision-making and patient management.
Citation	Wang RJ, Hu Y, Guo SB. Chicken skin mucosa is independently associated with advanced colorectal adenoma with transmembrane member 16A potentially involved in this association. World J Gastroenterol 2026; In press

Received	2026-01-09 07:26
Peer-Review Started	2026-01-09 07:26
First Decision by Editorial Office Director	2026-02-26 07:36
Return for Revision	2026-02-26 07:36
Revised	2026-04-01 10:08
Publication Fee Transferred
Second Decision by Editor	2026-05-06 03:20
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-06 07:19
Articles in Press	2026-05-06 07:19
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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