Publication Name	World Journal of Clinical Oncology
Manuscript ID	118494
Country	China

Category	Oncology
Manuscript Type	Minireviews
Article Title	Radiation-induced cardiotoxicity in lung cancer: Current landscape and future directions
Manuscript Source	Invited Manuscript
All Author List	Xiao-Luan Lin, Jia-Rong Li and Ren-Xian Xie
Funding Agency and Grant Number
Corresponding Author	Ren-Xian Xie, Department of Radiation Oncology, Cancer Hospital of Shantou University Medical College, No. 7 Raoping Road, Shantou 515000, Guangdong Province, China. 21rxxie@stu.edu.cn
Key Words	Radiation-induced heart disease; Lung cancer; Cardiotoxicity; Dose-volume parameters; Immunotherapy; Cardio-oncology
Core Tip	This mini-review examines the evolving comprehension of radiation-induced cardiotoxicity in lung cancer, emphasizing the transition from whole-heart to cardiac substructure-focused dose evaluation and risk prediction. The primary focus is on utilizing advanced predictive modeling techniques, such as radiomics and machine learning, to achieve personalized risk stratification. Importantly, the methodological paradigm developed for predicting radiation pneumonitis is highlighted as a crucial surrogate framework for creating analogous models for cardiotoxicity, given the similarities in injury mechanisms and data-driven modeling approaches. Additionally, the review underscores the essential need for integrated cardio-oncology management strategies in the context of combination therapies involving immunotherapy and targeted agents, with the goal of maintaining long-term cardiovascular health without compromising oncologic outcomes.
Citation	Lin XL, Li JR, Xie RX. Radiation-induced cardiotoxicity in lung cancer: Current landscape and future directions. World J Clin Oncol 2026; In press

Received	2026-01-04 05:46
Peer-Review Started	2026-01-04 05:48
First Decision by Editorial Office Director	2026-01-12 09:14
Return for Revision	2026-01-12 09:14
Revised	2026-02-19 06:47
Publication Fee Transferred
Second Decision by Editor	2026-05-19 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-19 04:19
Articles in Press	2026-05-19 04:19
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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