Publication Name	World Journal of Gastroenterology
Manuscript ID	118502
Country	Greece

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Epigenetic landscape of gastrointestinal stromal tumors: Mechanistic insights and therapeutic opportunities
Manuscript Source	Invited Manuscript
All Author List	Stavros P Papadakos, Georgios Mandrakis, Spyros I Siakavellas, Nikolaos Memos, Hara Gakiopoulou, Dimitrios Schizas and Stamatios Theocharis
Funding Agency and Grant Number
Corresponding Author	Stavros P Papadakos, First Academic Department of Gastroenterology, National and Kapodistrian University of Athens, General Hospital of Athens “Laiko”, Agiou Thoma 17, Athens 11527, Greece. stavrospapadakos@gmail.com
Key Words	Gastrointestinal stromal tumor; Epigenetics; DNA methylation; Histone modifications; Chromatin remodeling; Therapeutic resistance; Biomarkers
Core Tip	Gastrointestinal stromal tumors (GISTs) are driven primarily by KIT or PDGFRA mutations, yet therapeutic resistance and heterogeneous clinical behavior remain major challenges. This review highlights how epigenetic mechanisms DNA methylation, histone modifications, and chromatin remodeling shape GIST initiation, progression, and treatment response. We synthesize preclinical and clinical evidence linking epigenetic alterations to prognosis, resistance, and emerging therapeutic vulnerabilities, and discuss how chromatin-directed strategies may complement tyrosine kinase inhibition to advance precision oncology in GIST.
Citation	Papadakos SP, Mandrakis G, Siakavellas SI, Memos N, Gakiopoulou H, Schizas D, Theocharis S. Epigenetic landscape of gastrointestinal stromal tumors: Mechanistic insights and therapeutic opportunities. World J Gastroenterol 2026; In press

Received	2026-01-04 06:14
Peer-Review Started	2026-01-04 06:17
First Decision by Editorial Office Director	2026-01-23 10:01
Return for Revision	2026-01-23 10:01
Revised	2026-01-29 18:56
Publication Fee Transferred
Second Decision by Editor	2026-02-13 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-13 06:33
Articles in Press	2026-02-13 06:33
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
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