Publication Name	World Journal of Hepatology
Manuscript ID	118508
Country	Brazil

Category	Gastroenterology & Hepatology
Manuscript Type	Opinion Review
Article Title	Survival gap in gallbladder cancer: Bridging tumor biology and healthcare system logistics
Manuscript Source	Invited Manuscript
All Author List	Bruno Mirandola Bulisani
Funding Agency and Grant Number
Corresponding Author	Bruno Mirandola Bulisani, MD, PhD, Department of Digestive Surgery, Centro Universitário FMABC Santo André, Brazil Centro Universitário FMABC, São Caetano do Sul 09551200, São Paulo, Brazil. brunomirandola@hotmail.com
Key Words	Gallbladder carcinoma; Incidental gallbladder cancer; Healthcare logistics; Referral pathways; Radical re-resection; Molecular stratification; Neoadjuvant therapy; Real-world evidence; Therapeutic window; Hepatobiliary surgery
Core Tip	Gallbladder cancer (GBC) prognosis is traditionally viewed through the lens of aggressive tumor biology. However, in intermediate-incidence regions like Brazil, systemic fragmentation often prevents curative intent. This opinion review proposes a paradigm shift: Classifying healthcare logistics as a modifiable prognostic factor. By integrating molecular stratification, focusing on TP53 and HER2, with logistical “auto-alerts” and neoadjuvant “biological filters”, we can bridge the survival gap. Optimizing the “therapeutic window” between incidental diagnosis and radical surgery is as crucial as the surgical technique itself in transforming GBC outcomes.
Citation	Bulisani BM. Survival gap in gallbladder cancer: Bridging tumor biology and healthcare system logistics. World J Hepatol 2026; In press

Received	2026-01-12 01:41
Peer-Review Started	2026-01-12 01:42
First Decision by Editorial Office Director	2026-01-23 10:06
Return for Revision	2026-01-23 12:17
Revised	2026-02-06 05:27
Publication Fee Transferred
Second Decision by Editor	2026-04-22 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-22 08:04
Articles in Press	2026-04-22 08:04
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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