Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	118522
Country	China

Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Lenvatinib and pembrolizumab plus FOLFOX-hepatic arterial infusion chemotherapy in locally advanced, potentially resectable hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Xi Chen, Hao Liao, Jie Chen, Lin-hui Peng, Ji-Hao Zhang, Xiu-Xiu Xuyun, Ya-Jin Chen and Tao Chen
Funding Agency and Grant Number	Funding Agency Grant Number Guangdong Basic and Applied Basic Research Foundation Project No. 2024A1515220164
Corresponding Author	Tao Chen, PhD, Department of Hepatobiliary Surgery, Sun Yat-sen Memorial Hospital, No. 107 Yanjiang West Road, Yuexiu District, Guangzhou 510120, Guangdong Province, China. ct0498@126.com
Key Words	Hepatocellular carcinoma; Conversion therapy; Transhepatic arterial perfusion chemotherapy; Lenvatinib; Pembrolizumab
Core Tip	This retrospective study of 38 patients with initially unresectable hepatocellular carcinoma treated with hepatic arterial infusion chemotherapy, lenvatinib and pembrolizumab showed promising results. The overall response rate was 50.0%-52.6% with a disease control rate of 97.4%. The conversion to surgery rate was 44.7%, with a pathological complete response rate of 7.9%. Treatment was well-tolerated, with only 10.5% experiencing grade III/IV adverse events. Patients achieving successful conversion had significantly better long-term survival.
Citation	Chen X, Liao H, Chen J, Peng LH, Zhang JH, Xuyun XX, Chen YJ, Chen T. Lenvatinib and pembrolizumab plus FOLFOX-hepatic arterial infusion chemotherapy in locally advanced, potentially resectable hepatocellular carcinoma. World J Gastrointest Oncol 2026; In press

Received	2026-01-05 08:37
Peer-Review Started	2026-01-05 08:38
First Decision by Editorial Office Director	2026-01-20 10:26
Return for Revision	2026-01-20 11:11
Revised	2026-02-04 06:29
Publication Fee Transferred	2026-02-05 10:21
Second Decision by Editor	2026-03-25 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-25 04:29
Articles in Press	2026-03-25 04:29
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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