Publication Name	World Journal of Stem Cells
Manuscript ID	118524
Country	Russia

Category	Cell & Tissue Engineering
Manuscript Type	Letter to the Editor
Article Title	Impact of differentiation protocols on the functionality of mesenchymal stem cells: Temporal modulation of aging-related changes
Manuscript Source	Unsolicited Manuscript
All Author List	Ilya D Klabukov, Anna Smirnova, Yana Sulina and Denis S Baranovskii
Funding Agency and Grant Number
Corresponding Author	Ilya D Klabukov, Associate Professor, Head, PhD, Department of Regenerative Medicine, National Medical Research Radiological Center, 4 Koroleva Street, Obninsk 249036, Kaluzhskaya Oblast’, Russia. ilya.klabukov@gmail.com
Key Words	Adverse events; Aging; Cell therapy; Immunosenescence; Mesenchymal stem cells; Rejuvenation; Senescence-associated secretory phenotype; Senescence
Core Tip	Mesenchymal stem cells (MSCs) show promise in regenerative medicine, but their use in elderly patients requires careful consideration. Aging presents unique challenges, such as immunosenescence, an increased risk of cancer, cellular senescence, and vascular complications. These challenges underscore the necessity of rigorous preclinical and clinical studies to evaluate the safety and efficacy of MSC therapy. This could lead to a reevaluation of the role of some of MSC subpopulations as novel unconventional therapeutic targets.
Citation	Klabukov ID, Smirnova A, Sulina Y, Baranovskii DS. Impact of differentiation protocols on the functionality of mesenchymal stem cells: Temporal modulation of aging-related changes. World J Stem Cells 2026; In press

Received	2026-01-05 08:24
Peer-Review Started	2026-01-05 08:28
First Decision by Editorial Office Director	2026-01-14 08:33
Return for Revision	2026-01-14 08:33
Revised	2026-01-20 09:07
Publication Fee Transferred
Second Decision by Editor	2026-02-24 02:52
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-24 08:57
Articles in Press	2026-02-24 08:57
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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