Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	118531
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Is salvage surgery necessary for non-R0 endoscopic resection of small rectal neuroendocrine tumors?
Manuscript Source	Invited Manuscript
All Author List	Shi-Yong Lin, Ze-Hua Li, Guo-Liang Xu, Jun Weng and Kun-Hao Bai
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82403973, 82373118 Guangdong Basic and Applied Basic Research Foundation 2023A1515010828
Corresponding Author	Kun-Hao Bai, Associate Chief Physician, MD, PhD, Department of Endoscopy, Sun Yat-sen University Cancer Center, No. 651 Dongfengdong Street, Yuexiu District, Guangzhou 510060, Guangdong Province, China. baikh@sysucc.org.cn
Key Words	Rectal neuroendocrine tumors; Endoscopic resection; Non-R0 resection; Salvage surgery; Follow-up
Core Tip	Rectal neuroendocrine tumors (r-NETs) are diminutive but potentially malignant neoplasms. The rate of R0 resection for endoscopic resection of small r-NETs is nearly 90%. However, there is still controversy about subsequent treatment options for patients with non-R0 endoscopically resected r-NETs. This retrospective study investigated 38 patients with non-R0 endoscopically resected r-NETs. Of these, 30 underwent salvage surgery while 8 received follow-up only. Postoperative pathology following salvage surgery indicated an absence of tumor cells in all 30 patients. No evidence of local tumor recurrence or distant metastasis was observed in all 38 patients during an average follow-up duration of 46.4 ± 14.8 months. These findings suggest that salvage surgery may not be essential for patients with non-R0 endoscopically resected r-NETs, with regular follow-up being a safe alternative.
Citation	Lin SY, Li ZH, Xu GL, Weng J, Bai KH. Is salvage surgery necessary for non-R0 endoscopic resection of small rectal neuroendocrine tumors? World J Gastrointest Oncol 2026; In press

Received	2026-01-05 03:22
Peer-Review Started	2026-01-05 03:23
First Decision by Editorial Office Director	2026-01-26 09:11
Return for Revision	2026-01-26 09:46
Revised	2026-02-07 16:35
Publication Fee Transferred
Second Decision by Editor	2026-03-19 02:33
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-19 08:24
Articles in Press	2026-03-19 08:24
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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