Publication Name	World Journal of Clinical Cases
Manuscript ID	118545
Country	Lebanon

Category	Ophthalmology
Manuscript Type	Case Report
Article Title	Surgical management of acute choroidal neovascularization related submacular hemorrhage: Three case reports
Manuscript Source	Invited Manuscript
All Author List	Georges El Mollayess, Mahmoud Jaroudi, Yehya Tlaiss, Rayan Itaoui and Bachir Abiad
Funding Agency and Grant Number
Corresponding Author	Yehya Tlaiss, Department of Ophthalmology, Clemenceau Medical Center, Beirut 1100, Beyrouth, Lebanon. yehyatlaiss@hotmail.com
Key Words	Submacular hemorrhage; Choroidal neovascularization; Alteplase; Tissue plasminogen activator; Pars plana vitrectomy; Anti-vascular endothelial growth factor; Neovascular age-related macular degeneration; Case report
Core Tip	Acute submacular hemorrhage (SMH) secondary to choroidal neovascularization (CNV) is a vision-threatening emergency with no universal management consensus. This case series highlights the role of pars plana vitrectomy with subretinal tissue plasminogen activator, gas tamponade, and adjunct anti-vascular endothelial growth factor therapy for rapid foveal blood displacement. By integrating representative cases with contemporary evidence, we propose a practical, case-based treatment algorithm to guide timely surgical decision-making and postoperative management in severe CNV-related SMH.
Citation	El Mollayess G, Jaroudi M, Tlaiss Y, Itaoui R, Abiad B. Surgical management of acute choroidal neovascularization related submacular hemorrhage: Three case reports. World J Clin Cases 2026; In press

Received	2026-01-06 06:44
Peer-Review Started	2026-01-06 06:48
First Decision by Editorial Office Director	2026-01-14 07:58
Return for Revision	2026-01-14 07:58
Revised	2026-01-24 16:08
Publication Fee Transferred
Second Decision by Editor	2026-02-05 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-05 07:24
Articles in Press	2026-02-05 07:24
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com