Publication Name	World Journal of Stem Cells
Manuscript ID	118557
Country	China

Category	Cell Biology
Manuscript Type	Basic Study
Article Title	miR-140-3p in exosomes derived from bone-marrow mesenchymal stem cells inhibits pyrotoisosis by targeting PTEN under high-glucose condition
Manuscript Source	Unsolicited Manuscript
All Author List	Yue Wu, Wen-Hui Yin, Hong-Jing Wang and Hui Cai
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Gansu Province 22JR5RA692 Lanzhou Youth Scientific and Technological Talent Innovation Project 2024-QN-38 Backbone and Young Talent Project for Provincial Health Commission GSWSQN2025-20 National Natural Science Foundation of China 82360498 Gansu Joint Scientific Research Fund Major Project 23JRRA1537 Central-Guided Local Science and Technology Development Found 25ZYJA003 Alpha Isotope Mass Production Technology and Targeted Radiopharmaceuticals Research GSTWS250108 Gansu Provincial Clinical Medical Research Center for Burn and Wound Repair 21JR7RA674
Corresponding Author	Hui Cai, The First Clinical Medical School, Lanzhou University, No. 222 Tianshui South Road, Chengguan District, Lanzhou 730000, Gansu Province, China. caialongteams@163.com
Key Words	Bone marrow mesenchymal stem cell-derived exosomes; Rat fibroblasts; MicroRNA; Phosphatase and tensin homolog; Pyroptosis
Core Tip	Specifically, extracellular vesicles derived from bone marrow mesenchymal stem cells contain miR-140-3p that inhibits pyroptosis in rat dermal fibroblasts caused by hyperglycaemic stimulation through direct inhibition of phosphatase and tensin homolog. By blocking the NLRP3/caspase-1/gasdermine-D-N-terminal-dependent pyroptosis pathway to promote fibroblast proliferation and migration. The miR-140-3p/phosphatase and tensin homolog axis has provided an attractive strategy to treat diabetic foot ulcers.
Citation	Wu Y, Yin WH, Wang HJ, Cai H. miR-140-3p in exosomes derived from bone-marrow mesenchymal stem cells inhibits pyrotoisosis by targeting PTEN under high-glucose condition. World J Stem Cells 2026; In press

Received	2026-02-03 10:02
Peer-Review Started	2026-02-03 10:02
First Decision by Editorial Office Director	2026-03-03 07:27
Return for Revision	2026-03-03 07:27
Revised	2026-03-18 02:49
Publication Fee Transferred	2026-03-20 01:47
Second Decision by Editor	2026-05-27 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-27 07:45
Articles in Press	2026-05-27 07:45
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com