Publication Name	World Journal of Clinical Cases
Manuscript ID	118582
Country	United States

Category	Critical Care Medicine
Manuscript Type	Meta-Analysis
Article Title	Combination of N-methyl-D-aspartate receptor antagonists and propofol for procedural sedation
Manuscript Source	Invited Manuscript
All Author List	Muhammad Shaheer Bin Faheem, Syed Tawassul Hassan, Faheem Feroze, Ayesha Khan, Syeda Umbreen Munir, Ali Khaliq, Syeda Takreem Fatima, Roni Mendonca and Salim Surani
Funding Agency and Grant Number
Corresponding Author	Salim Surani, FACP, FCCP, MD, Professor, Department of Medicine, University of Houston, 4302 University Drive, TX, 77004, United States. srsurani@hotmail.com
Key Words	N-methyl-D-aspartate receptor antagonists; Ketamine; Esketamine; Propofol; Procedural sedation
Core Tip	This meta-analysis of nineteen randomized controlled trials evaluates the safety and efficacy of combining N-methyl-D-aspartate receptor antagonists, specifically ketamine and esketamine, with propofol for procedural sedation. Our pooled analysis demonstrates that this combination significantly reduces the risk of hypotension and the need for respiratory interventions compared to propofol monotherapy. However, clinicians must remain vigilant regarding the increased risk of transient hallucinations. These findings support the use of Ketofol and esketamine-propofol as valuable, hemodynamically stable alternatives for sedation in diverse clinical settings.
Citation	Faheem MSB, Hassan ST, Feroze F, Khan A, Munir SU, Khaliq A, Fatima ST, Mendonca R, Surani S. Combination of N-methyl-D-aspartate receptor antagonists and propofol for procedural sedation. World J Clin Cases 2026; In press

Received	2026-01-06 07:15
Peer-Review Started	2026-01-06 07:15
First Decision by Editorial Office Director	2026-01-14 07:57
Return for Revision	2026-01-14 07:57
Revised	2026-01-21 04:02
Publication Fee Transferred
Second Decision by Editor	2026-02-04 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-04 04:03
Articles in Press	2026-02-04 04:03
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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