Publication Name	World Journal of Gastroenterology
Manuscript ID	118600
Country	China

Category	Oncology
Manuscript Type	Opinion Review
Article Title	Pristimerin attenuates spasmolytic polypeptide-expressing metaplasia via p57 (Cdkn1c)-mediated glycolytic reprogramming: A metabolic avenue for gastric cancer prevention
Manuscript Source	Invited Manuscript
All Author List	Jun-Hao Han, Kong-Rui Lu, Min Zhang and Guo-Hua Gong
Funding Agency and Grant Number
Corresponding Author	Guo-Hua Gong, Full Professor, Professor, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, No. 82 West College Road, Wenzhou 325035, Zhejiang Province, China. guohgong@wmu.edu.cn
Key Words	Spasmolytic polypeptide-expressing metaplasia; Gastric precancerous lesion; Cdkn1c (p57); Pristimerin; Glycolytic reprogramming
Core Tip	This opinion review discusses that the natural compound pristimerin reverses spasmolytic polypeptide-expressing metaplasia (SPEM), not only by alleviating high-dose tamoxifen-induced gastric mucosal damage and oxyntic atrophy but also by restoring parietal and chief cell lineages and suppressing abnormal proliferation. This work further identifies Cdkn1c (p57) as a metabolic checkpoint: P57 is downregulated in SPEM, upregulated by pristimerin, and required for its antiglycolytic and anti-SPEM effects in gastric organoids.
Citation	Han JH, Lu KR, Zhang M, Gong GH. Pristimerin attenuates spasmolytic polypeptide-expressing metaplasia via p57 (Cdkn1c)-mediated glycolytic reprogramming: A metabolic avenue for gastric cancer prevention. World J Gastroenterol 2026; In press

Received	2026-01-07 03:20
Peer-Review Started	2026-01-07 03:21
First Decision by Editorial Office Director	2026-02-26 07:34
Return for Revision	2026-02-26 07:34
Revised	2026-03-09 08:34
Publication Fee Transferred
Second Decision by Editor	2026-05-28 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-28 11:25
Articles in Press	2026-05-28 11:25
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com