Publication Name	World Journal of Gastroenterology
Manuscript ID	118638
Country	Austria

Category	Pathology
Manuscript Type	Opinion Review
Article Title	Synergistic antitumor effects of quercetin and triptolide in hepatocellular carcinoma via modulation of PI3K/AKT/mTOR and Nrf2 signaling pathways
Manuscript Source	Unsolicited Manuscript
All Author List	Irene Maier
Funding Agency and Grant Number
Corresponding Author	Irene Maier, PhD, Researcher, Department of Internal Medicine I, Medical University of Vienna, Währinger Gürtel 18-20, Vienna A-1090, Austria. irene.maier@meduniwien.ac.at
Key Words	Phytochemical; Polyphenol; Liver; Proliferation; Carcinoma
Core Tip	The combination of quercetin and triptolide demonstrates enhanced antitumor effects by reducing tumor growth and oxidative stress while modulating the protein kinase B/mammalian target of rapamycin signaling pathway. Plant-derived bioactive compounds and herbal formulations have shown promise in hepatocellular carcinoma therapy, particularly in combination regimens that exert anticancer and anti-inflammatory effects through modulation of the tumor microenvironment. Quercetin may also inhibit triptolide-induced liver injury and carcinogenesis by regulating the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin pathway, which is associated with cell proliferation.
Citation	Maier I. Synergistic antitumor effects of quercetin and triptolide in hepatocellular carcinoma via modulation of PI3K/AKT/mTOR and Nrf2 signaling pathways. World J Gastroenterol 2026; In press

Received	2026-01-07 06:12
Peer-Review Started	2026-01-07 06:12
First Decision by Editorial Office Director	2026-02-27 09:03
Return for Revision	2026-02-27 09:03
Revised	2026-03-28 21:36
Publication Fee Transferred
Second Decision by Editor	2026-05-09 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-09 11:45
Articles in Press	2026-05-09 11:45
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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