| Category |
Pharmacology & Pharmacy |
| Manuscript Type |
Basic Study |
| Article Title |
Tangwang formula ameliorates diabetic retinopathy by inhibiting cell apoptosis and regulating the intestinal microbiota and metabolic profiles
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
He Zhang, Jia-Xin Xing, Yi-Fei Yin, Jun Li, Chen-Xu Jing, Song-Yan Liu, Jin-Zhu Yin, Xiang Gao, Zu-Guo Liang, Tong-Yi Yuan, Hang Su, Ying-Qian Li, Ze-Yu Wang, Hai-Si Dong, Da-Qing Zhao, Da-Shi Ying, Zhen-Wei Zhou and Qing-Xia Huang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Noncommunicable Chronic Diseases-National Science and Technology Major Project |
No. 2023ZD0509300 |
| Science and Technology Development Plan Project of Jilin Province |
No. 20230402040GH |
| Jilin Province Undergraduate Innovation Training Program Project |
No. 202410199024 |
| Medical Center Project of Changchun University of Traditional Chinese Medicine Affiliated Hospital |
No. DXZX-04-08 |
|
| Corresponding Author |
Qing-Xia Huang, MD, Research Center of Traditional Chinese Medicine, The Affiliated Hospital to Changchun University of Chinese Medicine, No. 1478 Gongnong Road, Changchun 130021, Jilin Province, China. hqx19890928@163.com |
| Key Words |
Tangwang formula; Diabetic retinopathy; Cell apoptosis; Intestinal bacteria; Metabolic profiles |
| Core Tip |
This study identified the main active components of Tangwang formula (TWF) and explored its protective mechanism against diabetic retinopathy mice induced by streptozotocin using network pharmacology, molecular docking, 16S ribosomal RNA sequencing, and metabolomics analysis. Four key active components were identified in TWF that participated in regulating the inflammation and apoptosis. TWF might reduce blood glucose, and alleviate retinal injury by modulating the intestinal microbiota and metabolic homeostasis. These findings provide a theoretical basis for the clinical application of TWF in the treatment of diabetic retinopathy. |
| Citation |
Zhang H, Xing JX, Yin YF, Li J, Jing CX, Liu SY, Yin JZ, Gao X, Liang ZG, Yuan TY, Su H, Li YQ, Wang ZY, Dong HS, Zhao DQ, Ying DS, Zhou ZW, Huang QX. Tangwang formula ameliorates diabetic retinopathy by inhibiting cell apoptosis and regulating the intestinal microbiota and metabolic profiles. World J Diabetes 2026; In press |
