Publication Name	World Journal of Stem Cells
Manuscript ID	118674
Country	Egypt

Category	Biology
Manuscript Type	Review
Article Title	Stem cell-derived immune cells in pediatric cancer therapy: From bench to bedside
Manuscript Source	Invited Manuscript
All Author List	Dina A Tolan, Noura A A Ebrahim, Naif S AlAli, Hoda A Ahmed, Gharam A Alharshan and Aya Mohamed Adel Arafat
Funding Agency and Grant Number
Corresponding Author	Noura A A Ebrahim, Assistant Professor, Department of Oncologic Pathology, National Cancer Institute, Cairo University, 1st Kasr Alainy Street, Cairo 11796, Al Qāhirah, Egypt. npathologist@gmail.com
Key Words	Stem cell-derived immunotherapy; Pediatric oncology; Induced pluripotent stem cells; Chimeric antigen receptor-based cell therapy; Natural killer cells; Allogeneic immune effectors
Core Tip	Immune cells generated from pluripotent or hematopoietic stem cell sources -particularly natural killer cells, T lymphocytes, and dendritic cells - represent a promising next-generation platform for pediatric cancer immunotherapy. These systems enable standardized, renewable production and genetic optimization, offering an allogeneic alternative to patient-specific cellular products with lower graft-vs-host disease risk. Advances in cytokine modulation and genome editing technologies, including CRISPR/Cas9, have further strengthened antitumor efficacy. This review critically consolidates current preclinical and early-phase clinical findings; addresses manufacturing, safety, and pediatric ethical considerations; and defines strategic directions for clinical translation.
Citation	Tolan DA, Ebrahim NAA, AlAli NS, Ahmed HA, Alharshan GA, Arafat AMA. Stem cell-derived immune cells in pediatric cancer therapy: From bench to bedside. World J Stem Cells 2026; In press

Received	2026-01-08 06:45
Peer-Review Started	2026-01-08 06:46
First Decision by Editorial Office Director	2026-01-23 07:59
Return for Revision	2026-01-23 07:59
Revised	2026-01-30 13:53
Publication Fee Transferred
Second Decision by Editor	2026-03-16 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-23 04:08
Articles in Press	2026-03-23 04:08
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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