Publication Name	World Journal of Gastroenterology
Manuscript ID	118677
DOI	10.3748/wjg.118677
Country	Mexico

Category	Gastroenterology & Hepatology
Manuscript Type	Prospective Study
Article Title	Association between Clostridioides difficile colonization and inflammatory bowel disease activity in outpatients with remission
Manuscript Source	Unsolicited Manuscript
All Author List	Oscar Morado-Aramburo, Eric Ochoa-Hein, Ma T Pérez-Gutiérrez, María N Sánchez-Cruz, Miriam Bobadilla-del-Valle, Jesús K Yamamoto-Furusho, Alfredo Ponce-de-Leon and Jose Sifuentes-Osornio
Funding Agency and Grant Number
Corresponding Author	Eric Ochoa-Hein, MD, Department of Hospital Epidemiology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga #15, Col. Belisario Domínguez Sección XVI, Alcaldía Tlalpan, Mexico City 14080, Ciudad de México, Mexico. dr_eric_ochoa@yahoo.com.mx
Key Words	Clostridioides difficile; Inflammatory bowel diseases; Ulcerative colitis; Crohn disease; Asymptomatic infections; Outpatients; Prospective studies
Core Tip	This prospective study evaluated the association between Clostridioides difficile (C. difficile) colonization (CDC) and inflammatory bowel disease (IBD) flares in patients in remission at baseline. Using stringent diagnostic criteria, no association was observed between CDC and subsequent IBD activity during a median follow-up longer than 1 year. Although baseline prevalence and incidence of CDC were relatively high, C. difficile infection events were infrequent, and approximately 70% of participants remained free of disease flares. The observed association between younger age at IBD diagnosis and CDC warrants further investigation.
Citation	Morado-Aramburo O, Ochoa-Hein E, Pérez-Gutiérrez MT, Sánchez-Cruz MN, Bobadilla-del-Valle M, Yamamoto-Furusho JK, Ponce-de-Leon A, Sifuentes-Osornio J. Association between Clostridioides difficile colonization and inflammatory bowel disease activity in outpatients with remission. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.118677
PDF	118677-in-press.pdf

Received	2026-01-27 05:58
Peer-Review Started	2026-01-27 05:59
First Decision by Editorial Office Director	2026-03-12 08:51
Return for Revision	2026-03-12 08:51
Revised	2026-04-18 08:51
Publication Fee Transferred	2026-05-19 19:19
Second Decision by Editor	2026-06-04 02:54
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-04 06:10
Articles in Press	2026-06-04 06:10
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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