Publication Name	World Journal of Hepatology
Manuscript ID	118687
Country	China

Category	Biology
Manuscript Type	Correspondence
Article Title	Letter to the Editor: Induction immunotherapy in hyperimmunized liver transplantation: Rebalancing immunological risk and graft protection
Manuscript Source	Invited Manuscript
All Author List	Jin-Wei Zhang
Funding Agency and Grant Number
Corresponding Author	Jin-Wei Zhang, PhD, Principal Investigator, Professor, State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, No. 345 Lingling Road, Shanghai 200032, China. jinweizhang@sioc.ac.cn
Key Words	Liver transplantation; Hyperimmunization; Donor-specific antibodies; Antibody-mediated rejection; Induction immunosuppression; Anti-T-lymphocyte globulin
Core Tip	For decades, hyperimmunized liver transplant recipients have faced poorer clinical outcomes due to their heightened immunological risk profile, leaving clinicians with limited evidence-based management options. This editorial delivers a comprehensive analysis of EL-Domiaty et al’s landmark study, which provides compelling clinical evidence that a short-course induction regimen of rabbit anti-T-lymphocyte globulin plus intravenous immunoglobulin can effectively mitigate early rejection risk and align outcomes with those of non-immunized recipients. This work highlights a viable, pragmatic strategy for managing this challenging patient population and paves the way for more personalized immunosuppression in liver transplantation.
Citation	Zhang JW. Letter to the Editor: Induction immunotherapy in hyperimmunized liver transplantation: Rebalancing immunological risk and graft protection. World J Hepatol 2026; In press

Received	2026-01-12 02:51
Peer-Review Started	2026-01-12 02:52
First Decision by Editorial Office Director	2026-03-27 04:01
Return for Revision	2026-03-27 04:01
Revised	2026-03-27 13:00
Publication Fee Transferred
Second Decision by Editor	2026-05-08 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-08 08:17
Articles in Press	2026-05-08 08:17
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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