Publication Name	World Journal of Gastroenterology
Manuscript ID	118689
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Prospective Study
Article Title	Serum anti-enteric neuronal antibodies in patients with achalasia and their association with clinical profiles
Manuscript Source	Unsolicited Manuscript
All Author List	Yao-Wen Hu, Pan Tang, Tao Guo, Zhi-Feng Wang, Xiu-Cai Fang, Li-Ming Zhu, Gui-Jun Fei, Yang Chen and Xiao-Qing Li
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 81970476
Corresponding Author	Xiao-Qing Li, MD, Professor, Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifuyuan, Dongcheng District, Beijing 100730, China. lixiaoqing20060417@126.com
Key Words	Achalasia; Anti-enteric neuronal antibody; Enteric nervous system; Disease severity; Treatment outcome
Core Tip	Serum anti-enteric neuronal antibodies (AENA) are significantly more prevalent in patients with achalasia than in healthy subjects. This study identifies a novel dose-dependent association between AENA intensity and endoscopic disease severity, as assessed by the CARS (contents, anatomy, resistance, and stasis) score. Strong AENA positivity correlates with greater esophageal dilation and higher integrated relaxation pressure. Furthermore, AENA positivity is associated with less favorable symptomatic improvement after peroral endoscopic myotomy. These findings suggest that AENA status may serve as a valuable biomarker for identifying a more severe disease phenotype with poorer early treatment outcomes.
Citation	Hu YW, Tang P, Guo T, Wang ZF, Fang XC, Zhu LM, Fei GJ, Chen Y, Li XQ. Serum anti-enteric neuronal antibodies in patients with achalasia and their association with clinical profiles. World J Gastroenterol 2026; In press

Received	2026-01-19 07:26
Peer-Review Started	2026-01-19 07:27
First Decision by Editorial Office Director	2026-02-26 07:46
Return for Revision	2026-02-26 07:46
Revised	2026-03-10 19:05
Publication Fee Transferred	2026-03-11 10:06
Second Decision by Editor	2026-04-15 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-15 04:06
Articles in Press	2026-04-15 04:06
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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