Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	118698
DOI	10.4251/wjgo.118698
Country	China

Category	Pharmacology & Pharmacy
Manuscript Type	Retrospective Study
Article Title	Interaction between calcium channel blockers and capecitabine in colorectal cancer patients with hypertension
Manuscript Source	Unsolicited Manuscript
All Author List	Hua-Cheng Lou, Xiao-Hua Liu, Ping Jin, Jian-Min Wang and Bin Liu
Funding Agency and Grant Number
Corresponding Author	Bin Liu, Associate Chief Pharmacist, Department of Pharmacy, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, No.116 Zhuodaoquan South Road, Hongshan District, Wuhan 430079, Hubei Province, China. liubinyl2024@163.com
Key Words	Colorectal cancer; Hypertension; Calcium channel blockers; Capecitabine; Amlodipine
Core Tip	The current research paper examines the effects of combining calcium channel blockers and capecitabine on the treatment of colorectal cancer patients with associated hypertension. The results show that the use of amlodipine is more effective than valsartan in reducing tumor marker levels (carcinoembryonic antigen and carbohydrate antigen 19-9) with a better blood pressure control effect when combined with capecitabine. Therefore, there appears to be an interaction between calcium channel blockers and chemotherapy drugs that can be used to develop personalized anti-hypertensive therapy among colorectal cancer patients.
Citation	Lou HC, Liu XH, Jin P, Wang JM, Liu B. Interaction between calcium channel blockers and capecitabine in colorectal cancer patients with hypertension. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.118698

Received	2026-03-06 10:01
Peer-Review Started	2026-03-06 10:02
First Decision by Editorial Office Director	2026-04-30 06:33
Return for Revision	2026-04-30 06:33
Revised	2026-05-13 07:36
Publication Fee Transferred	2026-05-15 08:18
Second Decision by Editor	2026-06-12 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-12 06:24
Articles in Press	2026-06-12 06:24
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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