Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	118718
DOI	10.4253/wjge.118718
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Celiac disease onset and inflammatory milieu
Manuscript Source	Unsolicited Manuscript
All Author List	Edward John Ciaccio, Randi L Wolf, Carolina Ciacci, Peter H Green and U Rajendra Acharya
Funding Agency and Grant Number
Corresponding Author	Edward John Ciaccio, Senior Scientist, Department of Medicine, Celiac Disease Center, Columbia University College of Physicians and Surgeons, HP 9-943, 180 Fort Washington Avenue, New York, NY 10032, United States. ciaccio@columbia.edu
Key Words	Celiac disease; Gastrointestinal endoscopy; Gluten; Immunogenic; Inflammation
Core Tip	In this article, the relationship between celiac disease and the inflammatory milieu is discussed and contrasted. The effects of inflammation on disease onset and recovery on a gluten-free diet are described in detail. After thoroughly covering the published literature, we suggest a hypothesis-generating paradigm that may possibly reduce the odds of a susceptible person developing the disease, and reduce the time needed for recovery after diagnosis. The paradigm reflects biologic plausibility and emerging mechanistic evidence, rather than clinical endorsement. The growing relevance of these concepts to modern gastrointestinal endoscopic technique is then highlighted.
Citation	Ciaccio EJ, Wolf RL, Ciacci C, Green PH, Acharya UR. Celiac disease onset and inflammatory milieu. World J Gastrointest Endosc 2026; In press DOI: https://doi.org/10.4253/wjge.118718
PDF	118718-in-press.pdf

Received	2026-01-12 06:08
Peer-Review Started	2026-01-12 06:08
First Decision by Editorial Office Director	2026-01-21 09:03
Return for Revision	2026-01-21 09:03
Revised	2026-02-03 17:16
Publication Fee Transferred	2026-07-20 16:52
Second Decision by Editor	2026-07-29 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-29 09:28
Articles in Press	2026-07-29 09:28
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5190 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	In this article, the relationship between celiac disease and the inflammatory milieu is discussed and contrasted. The effects of inflammation on disease onset and recovery on a gluten-free diet are described in detail. After thoroughly covering the published literature, we suggest a hypothesis-generating paradigm that may possibly reduce the odds of a susceptible person developing the disease, and reduce the time needed for recovery after diagnosis. The paradigm reflects biologic plausibility and emerging mechanistic evidence, rather than clinical endorsement. The growing relevance of these concepts to modern gastrointestinal endoscopic technique is then highlighted.
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