Publication Name	World Journal of Clinical Oncology
Manuscript ID	118731
Country	China

Category	Oncology
Manuscript Type	Minireviews
Article Title	Spatially fractionated radiotherapy: Integrated dose heterogeneity and radiobiology for bulky tumor
Manuscript Source	Unsolicited Manuscript
All Author List	Ling-Ling Meng, Lin Ma, Bao-Lin Qu and Yu-Peng Di
Funding Agency and Grant Number
Corresponding Author	Yu-Peng Di, Department of Radiotherapy, Air Force Medical Center, Air Force Medical University, Beijing 100142, PR China, Fucheng Road28, Beijing 100142, China. diyupeng0723@126.com
Key Words	Spatially fractionated radiotherapy; Dose heterogeneity; Normal tissue sparing; Bystander-abscopal effects; Bulky radioresistant tumors
Core Tip	Spatially fractionated radiotherapy (SFRT) offers a novel solution to the clinical challenge of treating bulky tumors. By creating controlled dose heterogeneity (“peaks” and “valleys”), SFRT leverages the regenerative capacity of normal tissues to maximize sparing while potentially triggering systemic antitumor immunity via bystander and abscopal effects. This article critically examines the dual mechanistic pathways of SFRT-integrating physical dose modulation with biological signaling-and reviews emerging clinical evidence suggesting its potential to safely expand the therapeutic index for difficult-to-treat malignancies.
Citation	Meng LL, Ma L, Qu BL, Di YP. Spatially fractionated radiotherapy: Integrated dose heterogeneity and radiobiology for bulky tumor. World J Clin Oncol 2026; In press

Received	2026-01-12 03:26
Peer-Review Started	2026-01-12 03:35
First Decision by Editorial Office Director	2026-02-12 08:19
Return for Revision	2026-02-12 08:19
Revised	2026-02-21 05:07
Publication Fee Transferred	2026-03-31 06:03
Second Decision by Editor	2026-05-08 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-08 08:49
Articles in Press	2026-05-08 08:49
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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