Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	118750
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Patient-derived organoids: A new platform for mechanism research and drug development of gastric intestinal metaplasia
Manuscript Source	Invited Manuscript
All Author List	Jin-Yan Deng, Hong-Bo Du and Xiao-Bin Zao
Funding Agency and Grant Number
Corresponding Author	Xiao-Bin Zao, Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, No. 5 Haiyuncang Road, Dongcheng District, Beijing 100700, China. a3417@bucm.edu.cn
Key Words	Gastric intestinal metaplasia; Patient-derived organoids; Helicobacter pylori infection; Bile acids; Transgenic mice
Core Tip	Gastric intestinal metaplasia (GIM) is a precancerous lesion in gastric carcinogenesis. Organoid technology has overcome the limitations of previous models by preserving patient-specific molecular features. A recent study by Liu et al identified taurine as a potential drug for suppressing GIM in patient-derived organoids and mouse models. Future research should prioritize the use of patient-derived organoids to study GIM pathogenesis and advance drug development more precisely.
Citation	Deng JY, Du HB, Zao XB. Patient-derived organoids: A new platform for mechanism research and drug development of gastric intestinal metaplasia. World J Gastrointest Oncol 2026; In press

Received	2026-01-12 02:58
Peer-Review Started	2026-01-12 02:58
First Decision by Editorial Office Director	2026-01-30 08:54
Return for Revision	2026-01-30 08:54
Revised	2026-02-11 16:09
Publication Fee Transferred
Second Decision by Editor	2026-03-18 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-18 05:56
Articles in Press	2026-03-18 05:56
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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