Publication Name	World Journal of Diabetes
Manuscript ID	118754
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Minireviews
Article Title	Unlocking pancreatic metabolic memory: Can early interventions reverse obesity and block diabetes before it strikes?
Manuscript Source	Invited Manuscript
All Author List	Yu-Jue Wang, Shuai-Yan Wang, Zi-Mu Li, Meng-Ying Zhao, Mo Zhou, Cong-Yi Xie, Jin-Ai Wang, Bin Xu, Guan-Hu Yang, Yun Liu and Tian-Cheng Xu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China Youth Science Fund Project No. 82305376 Young Talent Support Program of the China Association for Acupuncture-Moxibustion No. 2024-2026ZGZJXH-QNRC005 2024 Jiangsu Provincial Young Scientific and Technological Talent Support Program No. JSTJ-2024-380 Talent Cultivation Program for Young Researchers, Key Laboratory of the Ministry of Education Project No. Zyqt202501 and No. Zyqt202503
Corresponding Author	Tian-Cheng Xu, Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, No. 138 Xianlin Avenue, Qixia District, Nanjing 210023, Jiangsu Province, China. xtc@njucm.edu.cn
Key Words	Diabetes; Obesity; Metabolic Memory; Pancreas
Core Tip	Sustained exposure of pancreatic macrophages to metabolic stress (e.g., obesity, type 2 diabetes) triggers epigenetic reprogramming, leading to the establishment of a persistent “metabolic memory”. This memory maintains chronic local inflammation in the pancreas even after external stimuli subside, resulting in continuous deterioration of β-cell function and thereby driving the progression of type 2 diabetes. Targeting this maladaptive memory through lifestyle interventions or epigenetic modulators represents a highly promising early intervention strategy to halt the disease progression.
Citation	Wang YJ, Wang SY, Li ZM, Zhao MY, Zhou M, Xie CY, Wang JA, Xu B, Yang GH, Liu Y, Xu TC. Unlocking pancreatic metabolic memory: Can early interventions reverse obesity and block diabetes before it strikes? World J Diabetes 2026; In press

Received	2026-01-12 01:29
Peer-Review Started	2026-01-22 00:41
First Decision by Editorial Office Director	2026-02-06 09:32
Return for Revision	2026-02-06 09:32
Revised	2026-02-13 01:28
Publication Fee Transferred
Second Decision by Editor	2026-03-09 02:54
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-17 05:46
Articles in Press	2026-03-17 05:46
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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