Publication Name	World Journal of Gastroenterology
Manuscript ID	118757
Country	Japan

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Three-dimensional psoas muscle volume and longitudinal changes as predictors of outcomes in older patients with advanced pancreatic cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Yu Akazawa, Masahiro Ohtani, Yosuke Murata, Tomoko Tanaka, Takuto Nosaka, Kazuto Takahashi, Tatsushi Naito and Yasunari Nakamoto
Funding Agency and Grant Number	Funding Agency Grant Number Japan Society for the Promotion of Science KAKENHI Grant-in-Aid for Scientific Research 25K19290
Corresponding Author	Yasunari Nakamoto, MD, PhD, Professor, Department of Gastroenterology, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuoka Shimoaizuki, Eiheiji-Cho, Yoshida-Gun, Fukui 910-1193, Japan. nakamoto-med2@med.u-fukui.ac.jp
Key Words	Pancreatic cancer; Chemotherapy; Sarcopenia; Skeletal muscle volumetric analysis; Muscle volume dynamics; Tolerability; Prognosis
Core Tip	Sarcopenia is increasingly recognized as a key determinant of survival outcomes in various cancers. In this study, a three-dimensional psoas volume index was used to evaluate skeletal muscle dynamics in relation to clinical outcomes in older patients with advanced pancreatic cancer undergoing gemcitabine plus nab-paclitaxel therapy. Baseline sarcopenia and early muscle deterioration were strongly associated with poor tolerability, shorter time to treatment failure, and markedly reduced survival. These findings highlight that volumetric skeletal muscle assessment before and during chemotherapy may help predict clinical outcomes and contribute to more individualized treatment optimization in older patients with pancreatic cancer.
Citation	Akazawa Y, Ohtani M, Murata Y, Tanaka T, Nosaka T, Takahashi K, Naito T, Nakamoto Y. Three-dimensional psoas muscle volume and longitudinal changes as predictors of outcomes in older patients with advanced pancreatic cancer. World J Gastroenterol 2026; In press

Received	2026-01-12 06:15
Peer-Review Started	2026-01-12 06:15
First Decision by Editorial Office Director	2026-02-06 10:44
Return for Revision	2026-02-06 10:44
Revised	2026-02-17 15:33
Publication Fee Transferred	2026-02-18 13:22
Second Decision by Editor	2026-03-23 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-23 10:02
Articles in Press	2026-03-23 10:02
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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