Publication Name	World Journal of Gastroenterology
Manuscript ID	118763
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Opinion Review
Article Title	Prophylactic hyperthermic intraperitoneal chemotherapy for gastric cancer: Current evidence, persistent uncertainties, and future perspectives
Manuscript Source	Invited Manuscript
All Author List	Ze-Wei Cheng, Yi-Ze Liang, Meng Wei, Zhi-Bo Yan, Guo-Rui Sun, Xiao-Han Cui and Wen-Bin Yu
Funding Agency and Grant Number	Funding Agency Grant Number Horizontal Project of Shandong University No. 6010123193, No. 6010121066, and No. 6010125120
Corresponding Author	Wen-Bin Yu, MD, PhD, Professor, Department of General Surgery, Qilu Hospital of Shandong University, No. 107 Wenhuaxi Road, Jinan 250012, Shandong Province, China. wenbin_yu2003@163.com
Key Words	Gastric cancer; Prophylactic hyperthermic intraperitoneal chemotherapy; Peritoneal recurrence; Patient selection; Safety; Prognosis
Core Tip	Prophylactic hyperthermic intraperitoneal chemotherapy aims to eliminate occult free cancer cells following curative gastrectomy for locally advanced gastric cancer, thereby reducing peritoneal recurrence. While meta-analyses suggest potential improvements in survival and peritoneal control, conflicting trial results and persistent protocol heterogeneity preclude definitive recommendations. Although prophylactic hyperthermic intraperitoneal chemotherapy appears generally safe, it carries distinct risks that demand vigilant monitoring, including renal impairment, pulmonary dysfunction, and hematologic toxicity. Optimal patient selection, guided by serosal invasion, nodal burden, diffuse histology, and positive peritoneal cytology, remains paramount. Ongoing trials and novel combinatorial strategies may help clarify its therapeutic role.
Citation	Cheng ZW, Liang YZ, Wei M, Yan ZB, Sun GR, Cui XH, Yu WB. Prophylactic hyperthermic intraperitoneal chemotherapy for gastric cancer: Current evidence, persistent uncertainties, and future perspectives. World J Gastroenterol 2026; In press

Received	2026-01-12 01:37
Peer-Review Started	2026-01-12 01:37
First Decision by Editorial Office Director	2026-02-04 10:02
Return for Revision	2026-02-04 10:02
Revised	2026-02-13 15:20
Publication Fee Transferred
Second Decision by Editor	2026-04-22 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-22 06:58
Articles in Press	2026-04-22 06:58
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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