Publication Name	World Journal of Gastroenterology
Manuscript ID	118782
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Clinical features and biomarker research advances in immunoglobulin 4-related digestive system disorders
Manuscript Source	Unsolicited Manuscript
All Author List	Yue Pan and Yu-Zhang Jiang
Funding Agency and Grant Number	Funding Agency Grant Number Open Research Project of the Huai'an ‘Tian Yixing’ Key Laboratory of Medical Laboratory Science HAP202004
Corresponding Author	Yu-Zhang Jiang, Professor, Department of Laboratory Medicine, The Affiliated Huai'an No. 1 People's Hospital of Nanjing Medical University, No. 1 West Huanghe Road, Huai’an 223300, Jiangsu Province, China. jyz8848@163.com
Key Words	Immunoglobulin 4-related disease; Biomarkers; Digestive system; Diagnosis; Pathogenesis
Core Tip	Given that Immunoglobulin-related digestive system disorders frequently mimic malignancies, leading to misdiagnosis, this review systematically maps the clinical spectrum from classical (pancreato-biliary) to rare (esophageal/mesenteric) manifestations. A key highlight is the paradigm shift from single-marker diagnosis to multidimensional biomarker assessment (e.g., plasma blasts, interferon-α-interleukin-33 axis). It focuses on the utility of these novel markers in monitoring disease activity and predicting fibrosis, providing evidence-based strategies for early recognition and personalized management.
Citation	Pan Y, Jiang YZ. Clinical features and biomarker research advances in immunoglobulin 4-related digestive system disorders. World J Gastroenterol 2026; In press

Received	2026-01-12 06:50
Peer-Review Started	2026-01-12 06:52
First Decision by Editorial Office Director	2026-01-19 09:04
Return for Revision	2026-01-19 09:04
Revised	2026-01-31 12:46
Publication Fee Transferred	2026-02-03 09:45
Second Decision by Editor	2026-03-16 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-16 11:48
Articles in Press	2026-03-16 11:48
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	Given that Immunoglobulin-related digestive system disorders frequently mimic malignancies, leading to misdiagnosis, this review systematically maps the clinical spectrum from classical (pancreato-biliary) to rare (esophageal/mesenteric) manifestations. A key highlight is the paradigm shift from single-marker diagnosis to multidimensional biomarker assessment (e.g., plasma blasts, interferon-α-interleukin-33 axis). It focuses on the utility of these novel markers in monitoring disease activity and predicting fibrosis, providing evidence-based strategies for early recognition and personalized management.
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