Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	118787
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Yiwei Xiaoyu granules mitigate spasmolytic polypeptide-expressing metaplasia -associated gastric mucosal damage by regulating WFDC2 and the miRNA-7/circRNA network
Manuscript Source	Unsolicited Manuscript
All Author List	Wan-Qun Chen, Ying-Yue Xu, He-Lin Pan, Min Duan, Hang Ma, Yan-Ping Li and Jin-Wei Zhang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 81904175 Chongqing Technological Innovation and Applied Development Special Project No. CSTB2022TIAD-KPX0187 Young Scholars Cultivation Program of the Spleen and Stomach Diseases Branch, China Association of Chinese Medicine 202557-001
Corresponding Author	Jin-Wei Zhang, PhD, Chongqing General Hospital, Chongqing University, Chongqing 400000, China. jinwei.zhang@cqu.edu.cn
Key Words	Spasmolytic polypeptide-expressing metaplasia; Spleen-stomach deficiency syndrome; Yiwei Xiaoyu granules; miR-7a-5p/Cdr1as; WFDC2
Core Tip	Spasmolytic polypeptide-expressing metaplasia (SPEM) represents a key precancerous stage of gastric carcinogenesis and frequently coexists with spleen-stomach deficiency syndrome (SSDS) in clinical practice. Using a combined tamoxifen-induced SPEM and SSDS mouse model, we demonstrate that Yiwei Xiaoyu granules exert sustained protective effects on gastric mucosa. Yiwei Xiaoyu granules bidirectionally regulates inflammatory cytokines, restores the miR-7a-5p/Cdr1as axis, and suppresses WFDC2 induction, thereby linking syndrome-based intervention with molecular mechanisms of gastric precancerous lesions.
Citation	Chen WQ, Xu YY, Pan HL, Duan M, Ma H, Li YP, Zhang JW. Yiwei Xiaoyu granules mitigate spasmolytic polypeptide-expressing metaplasia -associated gastric mucosal damage by regulating WFDC2 and the miRNA-7/circRNA network. World J Gastrointest Oncol 2026; In press

Received	2026-01-12 06:57
Peer-Review Started	2026-01-12 06:59
First Decision by Editorial Office Director	2026-02-03 08:20
Return for Revision	2026-02-03 08:20
Revised	2026-02-11 07:38
Publication Fee Transferred
Second Decision by Editor	2026-03-27 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-27 08:02
Articles in Press	2026-03-27 08:02
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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