Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	118791
Country	Italy

Category	Gastroenterology & Hepatology
Manuscript Type	Meta-Analysis
Article Title	Lactobacillus supplementation for Helicobacter pylori eradication in children: A language-inclusive systematic review and meta-analysis of efficacy and safety
Manuscript Source	Unsolicited Manuscript
All Author List	Vanessa Nadia Dargenio, Sara Ricciardi, Martina Begucci, Giovanni La grasta, Nadia Maggi, Costantino Dargenio, Stefania Paola Castellaneta, Fernanda Cristofori and Ruggiero Francavilla
Funding Agency and Grant Number
Corresponding Author	Fernanda Cristofori, MD, PhD, Department of Biomedical Science and Human Oncology, University of Bari, 1 Piazza Umberto I, Bari 70121, Puglia, Italy. fernandacristofori@gmail.com
Key Words	Probiotic; Lactobacillus; Helicobacter; Infection; Gastritis; Children
Core Tip	Adjunctive Lactobacillus supplementation significantly enhances Helicobacter pylori (H. pylori) eradication rates in children and reduces treatment-related adverse effects. Evidence from this meta-analysis, which includes a substantial number of non-English and Chinese studies, demonstrates that probiotics are particularly effective when combined with standard triple therapy and when administered at higher doses. These findings support Lactobacillus probiotics as a safe, effective, and globally relevant complementary strategy for optimizing pediatric H. pylori treatment.
Citation	Dargenio VN, Ricciardi S, Begucci M, La Grasta G, Maggi N, Dargenio C, Castellaneta SP, Cristofori F, Francavilla R. Lactobacillus supplementation for Helicobacter pylori eradication in children: A language-inclusive systematic review and meta-analysis of efficacy and safety. World J Clin Pediatr 2026; In press

Received	2026-01-12 07:07
Peer-Review Started	2026-01-12 07:08
First Decision by Editorial Office Director	2026-02-13 07:36
Return for Revision	2026-02-13 07:36
Revised	2026-02-17 16:28
Publication Fee Transferred	2026-05-06 12:52
Second Decision by Editor	2026-05-29 03:06
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-29 10:32
Articles in Press	2026-05-29 10:32
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2219-2808 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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