| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Gram-negative bacteria and endotoxins promote hepatocellular carcinoma progression through the recruitment of myeloid-derived suppressor cells
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yong Zhang, You-Lian Zhou, Xin Nie, Liang-Jie Zhang, Wei-Wei Xu, Jia-Qi Wang, Hai-Lan Zhao, Jing-Kui Xu, Jing Xu, Hao-Ming Xu, Jian-Hong Li, Wen-Qi Huang, Jing Yang, Yao-Xiang Yang, Qi Zhan, Yong Lin and Yu-Qiang Nie |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82203371 |
| Natural Science Foundation of Guangdong Province |
2022A1515010392 |
| Yu-Qiang Nie Key Laboratory of Digestive Diseases in 2022 |
KY17010003 |
| Doctoral Research Start-up Fund of Yichang Central People’s Hospital (2024) |
|
|
| Corresponding Author |
Yu-Qiang Nie, Dean, MD, Professor, Department of Gastroenterology and Hepatology, the Second Affiliated Hospital, School of Medicine; Guangzhou First People's Hospital, South China University of Technology, Panfu Road 1, Yuexiu District, Guangzhou 510180, Guangdong Province, China. eynieyuqiang@scut.edu.cn |
| Key Words |
Hepatocellular carcinoma; Intra-tumor bacteria; Endotoxins; Gram-negative bacteria; Myeloid-derived suppressor cells |
| Core Tip |
The presence of intratumoral bacteria was identified in a subset of hepatocellular carcinoma (HCC) cases. Gram-negative bacteria and their associated endotoxins were found to promote the recruitment of monocytic myeloid-derived suppressor cells through activation of the TLR4/CCL2/CCR2 signaling axis. This process may contribute to the establishment of an immunosuppressive tumor microenvironment, thereby influencing both tumor progression and clinical prognosis in HCC. Collectively, our findings identified lipopolysaccharide (LPS) as a potential prognostic biomarker for HCC and indicated that therapeutic targeting of the LPS/TLR4/CCL2/CCR2/monocytic myeloid-derived suppressor cell axis may represent a promising strategy for future HCC treatment. |
| Citation |
Zhang Y, Zhou YL, Nie X, Zhang LJ, Xu WW, Wang JQ, Zhao HL, Xu JK, Xu J, Xu HM, Li JH, Huang WQ, Yang J, Yang YX, Zhan Q, Lin Y, Nie YQ. Gram-negative bacteria and endotoxins promote hepatocellular carcinoma progression through the recruitment of myeloid-derived suppressor cells. World J Gastroenterol 2026; In press |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
