Publication Name	World Journal of Gastroenterology
Manuscript ID	118801
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Beyond local injury: Sarcopenia as a systemic host-related determinant of esophageal stenosis after endoscopic submucosal dissection
Manuscript Source	Invited Manuscript
All Author List	Wen-Mao Li, Bo Liu and Qing Liu
Funding Agency and Grant Number
Corresponding Author	Bo Liu, Assistant Professor, Department of Cadre’s Wards Ultrasound Diagnostics, Ultrasound Diagnostic Center, The First Hospital of Jilin University, Xinmin Street, Changchun 130021, Jilin Province, China. liubo_tengzhou@jlu.edu.cn
Key Words	Sarcopenia; Endoscopic submucosal dissection; Esophageal stenosis; Body composition; Wound healing; Fibrosis; Nutritional status; Risk stratification
Core Tip	Esophageal stenosis after endoscopic submucosal dissection has traditionally been regarded as a consequence of local mucosal injury. Emerging evidence indicates that sarcopenia, a systemic condition reflecting impaired nutritional reserve, inflammation, and reduced regenerative capacity, is independently associated with adverse post-endoscopic submucosal dissection outcomes. Recognizing sarcopenia as a host-related determinant of esophageal healing shifts risk assessment beyond lesion characteristics alone and supports more holistic peri-procedural management strategies.
Citation	Li WM, Liu B, Liu Q. Beyond local injury: Sarcopenia as a systemic host-related determinant of esophageal stenosis after endoscopic submucosal dissection. World J Gastroenterol 2026; In press

Received	2026-01-12 02:24
Peer-Review Started	2026-01-12 02:25
First Decision by Editorial Office Director	2026-02-13 07:55
Return for Revision	2026-02-13 07:55
Revised	2026-02-21 13:07
Publication Fee Transferred
Second Decision by Editor	2026-03-10 02:50
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-10 08:01
Articles in Press	2026-03-10 08:01
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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